Dietary medicinal plants are highly valuable in alternative medicine, with disease-preventing and healing properties that can improve overall well-being and reduce disease risk, revolutionizing healthcare.
Umbelliprenin, a compound found in Artemisia absinthium L., has demonstrated its ability to induce apoptosis and exhibit antitumor effects in different types of cancers. However, its potential role in treating human pancreatic cancer remains unclear. Investigating the antitumor effect of umbelliprenin specifically in pancreatic cancer could provide valuable insights into potential therapeutic options for this challenging disease.
In this study, researchers explored the mechanism behind the anti-cancer effects of L. rhizome extracts (KGEs). They found that KGEs inhibit the proliferation of Ehrlich ascites tumor cells by impacting cell cycle progression. The main component of KGEs, ethyl-methoxycinnamate (EMC), also displayed anti-proliferative effects. Additionally, EMC affected the expression of key proteins involved in cell cycle regulation, such as cyclin D1 and p21. Importantly, the study demonstrated that EMC and KGEs can suppress the growth of ascites fluid in mice with EATC. These findings provide valuable insights into the potential therapeutic applications of KGEs and EMC in cancer treatment.
In this study, researchers investigated the potential of Black Seed Oil (BSO) as a safer and less toxic alternative to traditional cancer treatments. They focused on the oil soluble phytochemicals found in BSO, specifically Thymoquinone, Carvacrol, and Trans-Anethole. When used together, these compounds showed promising results in inhibiting breast cancer cell migration and inducing apoptosis. Chemical characterization of the individual phytochemicals and the whole BSO extract confirmed their bioactive properties. The study also uncovered the role of microRNAs in regulating breast cancer progression and highlighted the synergistic action of the BSO components. This research provides valuable insights for developing more effective and targeted treatments for breast cancer.
The drug combination of Aiton (Kushen) and Franch. (Huanglian) is used to treat laxation. This study focused on their potential anti-cancer effects against colorectal cancer. The research found that a 1:1 ratio of Kushen and Huanglian had the best anti-cancer effect. The active components, matrine and berberine, were evaluated and found to reduce the growth of colorectal cancer in mice. Additionally, the combination of matrine and berberine showed better efficacy than using them alone. The study also identified and quantified the chemical constituents of the drug pair. The findings suggest that the combination of matrine and berberine could inhibit colorectal cancer by improving intestinal microbiota and regulating a signaling pathway.
This study explored the therapeutic properties of basil seed essential oil, including its antioxidant, anti-obesity, antidiabetic, antibacterial, and cytotoxic activities. It adds to the search for natural compounds for obesity, diabetes, infections, cancer, and oxidative stress.