Cancer Studies

Phenolic composition, antioxidant, and cytotoxic effects on HeLa and HepG2 cancer cell lines of Mespilus germanica grown in Turkey.

In this study, researchers examined the antioxidant and cytotoxic properties of flavonoids and phenolic acids found in Turkish medlar. Using advanced analysis techniques, they identified various compounds in leaf and fruit extracts. Notably, the fruit extract showed excellent antioxidant properties, while the leaf extract demonstrated strong cytotoxicity against cancer cells. These findings suggest that Turkish medlar could be a valuable natural source for developing anticancer and antioxidant agents in the food and pharmaceutical industries.

CancerImmunologyPhytochemistry Mespilus germanica
Yunusa UM and Ozturk Urek R (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2230612
PubMed:
37395516

A Standardized Extract of Petasites hybridus L., Containing the Active Ingredients Petasins, Acts as a Pro-Oxidant and Triggers Apoptosis through Elevating of NF-κB in a Highly Invasive Human Breast Cancer Cell Line.

A Bulgarian butterbur root extract, rich in petasins, was tested for its anti-cancer properties on breast cancer cells and non-cancerous cells. The study investigated cell death, oxidative stress, and NF-κB signaling. This research is important as it highlights the anti-tumor potential of a traditional medicinal plant, providing insights into possible future treatments for breast cancer.

CancerImmunology Petasites hybridus
Apostolova S et al (2023).
Front Biosci (Landmark Ed).
DOI:
10.31083/j.fbl2806111
PubMed:
37395030

In-silico and in-vitro assessments of some fabaceae, rhamnaceae, apocynaceae, and anacardiaceae species against Mycobacterium tuberculosis H37Rv and triple-negative breast cancer cells.

Medicinal plants in South Africa's Limpopo province have long been used to treat diseases like tuberculosis and cancer. In this study, researchers evaluated the antimycobacterial and cytotoxic activity of five plants, including Rauvolfia caffra and Schinus molle, against various strains of bacteria and breast cancer cells. The extracts from R. caffra and S. molle showed promising results, particularly against M. tuberculosis. Further analysis identified a compound called norajmaline as a potential lead for antimycobacterial treatment. Additionally, the extracts from Senna petersiana, Ziziphus mucronate, R. caffra, and S. molle demonstrated potential for treating triple-negative breast cancer. Further research is needed to validate these findings and explore chemical modifications for enhanced effectiveness.

Cancer Schinus molle
Nyambo K et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04041-5
PubMed:
37393246

Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.

New compounds with anti-inflammatory properties were found in the roots of L. These compounds showed even better effectiveness than a commonly used anti-inflammatory drug. Additionally, five of these compounds helped to enhance the effects of certain chemotherapeutic drugs against cervical cancer cells, including those resistant to paclitaxel. The combination of one particular compound and paclitaxel successfully promoted cancer cell death through a specific cellular pathway. This research could lead to new treatments for inflammatory diseases and cancer, offering hope for improved patient outcomes.

CancerImmunologyPhytochemistry Piper longum
Wan Q et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c01667
PubMed:
37392181

Synergism of antiproliferative effects of young green barley and chlorella water extracts against human breast cancer cells.

Researchers aimed to expand understanding of the potential benefits of using young green barley and chlorella to reduce the risk of breast cancer. These plant-based foods have shown chemopreventive properties in previous studies. However, limited scientific reports exist on their effect on breast cancer development. This study sought to contribute to the knowledge in this area, suggesting these foods as a reasonable therapeutic strategy in combating this common and deadly form of cancer.

Cancer Hordeum vulgare
Lemieszek MK and Rzeski W (2023).
Ann Agric Environ Med.
DOI:
10.26444/aaem/166267
PubMed:
37387377

Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production.

Researchers developed ZIF-DHA nanoparticles to enhance the anticancer properties of dihydroartemisinin (DHA) by improving its delivery to ovarian cancer cells and reducing cellular reactive oxygen species. The study suggests that ZIF-DHA nanoparticles could be a promising treatment for ovarian cancer. (40 words)

CancerEndocrinology Artemisia annua
Yan Y et al (2023).
J Nanobiotechnology.
DOI:
10.1186/s12951-023-01959-3
PubMed:
37386404

Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition.

Recent studies have found that morusin, a natural compound derived from the root bark of Morus Alba, shows promise in treating various types of cancers, such as breast, gastric, and prostate cancer. However, its effectiveness against melanoma cells remains unexplored. The discovery of new anti-melanoma drugs is urgently needed in the medical field, and understanding the potential of morusin could lead to the development of effective treatments with low side effects.

Cancer Morus alba
Liu W et al (2023).
BMC Cancer.
DOI:
10.1186/s12885-023-11080-1
PubMed:
37386395

A study on antimicrobial and anticancer properties of Cissus quadrangulris using lung cancer cell line.

A study was conducted to analyze the medicinal properties of the stem extract from the Cissus quadrangularis plant. The extract showed antimicrobial activity against various microorganisms and displayed potential in inhibiting the growth of A549 human lung cancer cells. In addition, the extract exhibited a dose-dependent reduction in lung cancer cell viability. Further analysis revealed that the IC50 dose, which inhibits 50% of cell growth, was achieved at a concentration of 65.2 μg/ml. These findings suggest that the Cissus quadrangularis stem extract may have potential as a natural anti-cancer agent.

AntimicrobialCancer Cissus quadrangularis
Payani S et al (2023).
Cancer Treat Res Commun.
DOI:
10.1016/j.ctarc.2023.100732
PubMed:
37379774
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