Cancer Studies

Matrine suppresses liver cancer progression and the Warburg effect by regulating the circROBO1/miR-130a-5p/ROBO1 axis.

Matrine, a compound extracted from a traditional Chinese herb, has been found to have anti-cancer properties in various types of cancer. However, its role in liver cancer has not been well understood. In this study, researchers investigated the effects of matrine on liver cancer cells. They found that matrine reduced cell viability and proliferation, while increasing cell apoptosis. Matrine also inhibited the Warburg effect, a metabolic characteristic of cancer cells. The researchers identified a specific molecular pathway involving circular RNA circROBO1, microRNA miR-130a-5p, and roundabout homolog 1 (ROBO1) that was influenced by matrine. In vivo experiments using a mouse model further supported the anti-cancer effects of matrine. This study provides scientific evidence supporting the potential use of matrine as an effective treatment for liver cancer.

Cancer Sophora flavescens
Huang Z et al (2023).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23436
PubMed:
37376914

Doxorubicin Activity Is Modulated by Traditional Herbal Extracts in a 2D and 3D Multicellular Sphere Model of Leukemia.

This study examined the impact of natural product extracts from P2Et and Anamú-SC plants on tumor cells, endothelial cells, and mesenchymal stem cells. The results revealed that the extracts selectively targeted tumor cells and were independent of intracellular ROS modulation. Additionally, the complexity of the extracts and the expression of Pgp influenced their interaction with chemotherapy drug doxorubicin. Interestingly, multicellular spheroids with MSC and EC showed modified effects on leukemia cell viability when treated with the extracts. This research provides insights into how botanical drugs can affect tumor microenvironments and contribute to understanding their pharmacodynamics.

Cancer Petiveria alliacea
Corzo Parada L et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15061690
PubMed:
37376139

The Protective Role of Cranberries and Blueberries in Oral Cancer.

Oral cancer, a prevalent global disease, is influenced by genetic, immunological, and environmental factors. Smoking and alcohol consumption are the main risk factors associated with oral cancer. Understanding these factors is essential in preventing and treating this deadly disease.

Cancer Vaccinium macrocarpon
Esquivel-Chirino C et al (2023).
Plants (Basel).
DOI:
10.3390/plants12122330
PubMed:
37375955

Use of Multivariate Analysis to Unravel the Differences between Two Chamomile Varieties and Their Anticancer and Antioxidant Activities.

Two varieties of chamomile (Jordanian and European) were studied to measure the depth of variation in their bioactive flavonoids and phenolics. These plants, both belonging to the Asteraceae family, have been traditionally used in treating diseases. The study found significant distinctions in the secondary metabolites produced by the two varieties. By employing multivariate statistical analysis, researchers were able to determine the extent of this variation. This research provides valuable insights into the diversity within plant species and highlights the potential for the development of targeted therapeutic applications.

CancerImmunology Matricaria chamomilla
Atoum D et al (2023).
Plants (Basel).
DOI:
10.3390/plants12122297
PubMed:
37375922

Exploring the Multi-Faceted Potential of Carob (Ceratonia siliqua var. Rahma) Leaves from Morocco: A Comprehensive Analysis of Polyphenols Profile, Antimicrobial Activity, Cytotoxicity against Breast Cancer Cell Lines, and Genotoxicity.

The Carob tree, also known as "L'Kharrûb" in Morocco, has been traditionally used for treating various ailments. To understand its properties, we analyzed the chemical composition of the ethanolic extract of carob leaves (CSEE) and conducted several tests. The CSEE extract, rich in phenolic acids and flavonoids, exhibited potent antioxidant activity, comparable to ascorbic acid. It also showed broad-spectrum antibacterial activity but moderate effectiveness against fungi. Additionally, the extract demonstrated dose-dependent inhibition of human breast cancer cell lines. At lower concentrations, it did not induce DNA damage, but a higher concentration showed genotoxic effects. Computational analysis predicted potential biological activities and evaluated the toxicity of the extract's constituents. This research provides valuable insights into the medicinal properties of the Carob tree.

AntimicrobialCancer Ceratonia siliqua
Elbouzidi A et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16060840
PubMed:
37375787

Urtica dioica Leaf Infusion Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Cisplatin Treatment.

A recent study investigated the potential of UD tea in combination with cisplatin as a treatment for breast cancer. The researchers conducted several tests on MDA-MB-231 breast cancer cells and found that the combination significantly reduced cell proliferation compared to each treatment alone. This effect was accompanied by increased signs of apoptosis, including changes in membrane composition and DNA fragmentation. Additionally, the study revealed that the combination increased DNA damage and altered the Bax/Bcl-2 ratio, further supporting the apoptotic mechanism. These findings suggest that UD tea could enhance the effectiveness of cisplatin in treating aggressive breast cancer.

Cancer Urtica dioica
Nafeh G et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16060780
PubMed:
37375728

Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile.

Pentagalloyl glucose (PGG), a natural compound, may have anticancer properties by inhibiting cancer pathways and enhancing chemotherapy and radiotherapy. Further research on its safety and pharmacokinetics is needed for clinical use.

Cancer Mangifera indicaRhus chinensis
Wen C et al (2023).
Molecules.
DOI:
10.3390/molecules28124856
PubMed:
37375411

Cytotoxic Compounds from Belamcanda chinensis (L.) DC Induced Apoptosis in Triple-Negative Breast Cancer Cells.

A recent study identified several compounds isolated from a specific plant species. These compounds were tested for their effects on tumor cell growth and metastasis. One compound in particular showed significant activity against two different types of breast cancer cells. Further investigation revealed that this compound caused cell cycle arrest, mitochondrial damage, and cell apoptosis. These findings suggest that this compound could be a potential treatment for triple-negative breast cancer. More research is needed to fully evaluate its effectiveness.

Cancer Belamcanda chinensis
Guo YP et al (2023).
Molecules.
DOI:
10.3390/molecules28124715
PubMed:
37375271
1 97 106 107 108 117 258