Cancer Studies

Khasianine Affects the Expression of Sugar-Sensitive Proteins in Pancreatic Cancer Cells, Which Are Altered in Data from the Rat Model and Patients.

Summary: This study investigated the antiproliferative activity of khasianine on pancreatic cancer cells. Khasianine, extracted from fruits, inhibited the growth of human and rat pancreatic cancer cell lines. The researchers identified sugar-sensitive proteins and found that khasianine downregulated lactose-sensitive proteins the most. Rhamnose-sensitive proteins were upregulated in pancreatic cancer patients and a rat model. The study also identified the Ras homolog family member A (RhoA) as a key signaling pathway. Overall, this research suggests that khasianine has potential as a treatment for pancreatic cancer.

Cancer Solanum incanum
Sagini MN et al (2023).
ACS Pharmacol Transl Sci.
DOI:
10.1021/acsptsci.3c00013
PubMed:
37200805

Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK.

The Zhuidu Formula (ZDF) contains triptolide, cinobufagin, and paclitaxel, derived from natural sources. Studies have shown that these compounds have anti-tumor properties by affecting DNA synthesis, promoting tumor cell death, and disrupting tubulin balance. However, their role in inhibiting triple-negative breast cancer (TNBC) metastasis remains unclear. Understanding this mechanism could lead to new treatments for TNBC.

Cancer Taxus wallichianaTripterygium wilfordii
Wu Q et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116644
PubMed:
37196814

Tetrastigma polysaccharide reprogramming of tumor-associated macrophages via PPARγ signaling pathway to play antitumor activity in breast cancer.

Tetrastigma Hemsleyanum Diels et Gilg (SYQ) is a traditional Chinese medicine used for anti-tumor treatment. Researchers have found that the polysaccharide component of SYQ has antioxidant and anti-inflammatory properties. However, its impact on antitumor activity and the underlying mechanism are not yet well understood. This research aims to uncover the potential benefits of SYQ-PA in fighting tumors, shedding light on its significance for future cancer treatments.

CancerImmunology Tetrastigma hemsleyanum
Liu X et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116645
PubMed:
37196813

KRAS Mutation Reduces Thymoquinone Anticancer Effects on Viability of Cells and Apoptosis.

Black cumin seeds, specifically the compound thymoquinone (TQ), show promising potential in cancer research. TQ, found in the essential oil of Nigella sativa, has various biological effects that make it a popular topic for phytotherapy studies. Researchers are working to understand its mechanisms of action, safety, and efficacy in humans. Additionally, TQ could be a valuable tool in treating cancer, as it may help overcome resistance to chemotherapy and targeted therapies caused by mutations in the KRAS gene, which regulates cell division and growth.

Cancer Nigella sativa
Betul Yenigun V et al (2023).
Anticancer Agents Med Chem.
DOI:
10.2174/1871520623666230517123807
PubMed:
37194932

Phytocompounds screening of Nigella sativa in terms of human cancer by targeting sphingosine kinase-1 and pyruvate kinase-M2: a study based on in silico analysis.

Scientists have discovered that certain plant compounds, such as epicatechin, apigenin, and kaempferol, have anticancer properties. These compounds were tested against two important proteins found in cancer cells, sphingosine kinase-1 (SK-1) and pyruvate kinase-M2 (PK-M2). Using advanced computational tools, researchers predicted the potential effectiveness, toxicity, and binding of these compounds. Molecular dynamics simulations confirmed that these compounds interact with the proteins, suggesting their potential for combatting cancer. This research provides valuable insights into developing new treatments for this complex disease.

Cancer Nigella sativa
Ahmed S and Tabish M (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2212773
PubMed:
37194426

Structure-based virtual screening of anti-breast cancer compounds from Artemisia absinthium-insights through molecular docking, pharmacokinetics, and molecular dynamic simulations.

A study investigated the potential use of a natural breast cancer medicine with low side effects. Researchers extracted and identified compounds from leaf powder using advanced technology. They then tested the compounds' ability to bind to breast cancer receptors and found that one compound, 3',4',5,7-Tetrahydroxyisoflavanone (THIF), showed stronger binding than standard drugs. Additional analysis showed that THIF had good drugability and lower toxicity. Molecular dynamics simulation revealed structural changes during protein-ligand interaction. Overall, this research suggests that THIF has potential as an anti-breast cancer drug. (Words: 79)

Cancer Artemisia absinthium
Gnanaselvan S, Yadav SA and Manoharan SP (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2212805
PubMed:
37194295

Ethyl acetate extract of Antenoron Filiforme inhibits the proliferation of triple negative breast cancer cells via suppressing Skp2/p21 signaling axis.

Researchers investigated the potential of Antenoron filiforme (AF), a Traditional Chinese Medicine, in treating triple negative breast cancer (TNBC). TNBC, which has a poor prognosis and limited therapeutic options, may benefit from AF's known anti-inflammatory, antioxidant, and anti-tumor properties. This study highlights AF's efficacy in gynecological diseases and suggests its potential as a novel treatment for TNBC.

Cancer Antenoron filiforme
Liao Y et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154856
PubMed:
37187035

Antioxidant and anticancer potential of ethyl acetate extract of bark and flower of Tecoma stans (Linn) and In Silico studies on phytoligands against Bcl 2 and VEGFR2 factors.

A study evaluated the antioxidant and anticancer properties of Tecoma stans extracts. The ethyl acetate extract contained the most valuable phytochemicals, particularly flavonoids. Purified flavonoid fractions were confirmed to be enriched. The ethyl acetate extract exhibited high antioxidant activity and dose-dependent cytotoxicity against breast cancer cells. Analysis identified 10 medicinal flavonoids, with 3,5-O-dicaffeoylquinic acid and Isorhamnetin-3-O-rutinoside showing potential interactions with Bcl 2 and VEGFR2, respectively. These findings suggest that T. stans extracts have significant medicinal potential as antioxidant and anticancer agents, pending further animal studies.

CancerImmunology Tecoma stans
Narayanan M et al (2023).
Environ Res.
DOI:
10.1016/j.envres.2023.116112
PubMed:
37182829
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