GeoBotanical: Cancer Studies

769.

Isoalantolactone Suppresses Glycolysis and Resensitizes Cisplatin-Based Chemotherapy in Cisplatin-Resistant Ovarian Cancer Cells.

Isoalantolactone, a compound found in Herba Inulae, can inhibit glycolysis in cisplatin-resistant ovarian cancer cells and sensitize them to cisplatin-induced apoptosis. It also suppresses tumor growth in cisplatin-resistant tumors, offering a potential treatment for overcoming drug resistance in ovarian cancer.

Cancer Endocrinology Inula helenium

Chun J et al (2023).; Int J Mol Sci.
DOI:: 10.3390/ijms241512397
PubMed:: 37569773

770.

Viscum album Induces Apoptosis by Regulating STAT3 Signaling Pathway in Breast Cancer Cells.

This study investigated the anticancer effects of a parasitic plant (VaM) on breast cancer cells. VaM inhibited cell growth, induced cell death, and suppressed cancer signaling pathways. Combining VaM with low-dose doxorubicin showed promising results in treating breast cancer.

Cancer Immunology Viscum album

Park YR et al (2023).; Int J Mol Sci.
DOI:: 10.3390/ijms241511988
PubMed:: 37569363

771.

A novel flavonol glycoside and six derivatives of quercetin and kaempferol from Clematis flammula with antioxidant and anticancer potentials.

Clematis flammula leaves contain a new flavonol compound and six known flavonol molecules. The extract has antioxidant properties and shows promise in treating hepatoma and ovarian cancer.

Cancer Immunology Phytochemistry Clematis flammula

Medjahed Z et al (2023).; Fitoterapia.
DOI:: 10.1016/j.fitote.2023.105642
PubMed:: 37567483

772.

Effects of a mucoadhesive phytomedicine (Curcuma longa L. and Bidens pilosa L.) on radiotherapy-induced oral mucositis and quality of life of patients undergoing head and neck cancer treatment: randomized clinical trial.

This study evaluated the effectiveness of a herbal medicine combined with photobiomodulation therapy and an oral care program in treating radiotherapy-induced oral mucositis and improving patients' quality of life.

Cancer Bidens pilosa Curcuma longa

Martins AFL et al (2023).; Support Care Cancer.
DOI:: 10.1007/s00520-023-07971-5
PubMed:: 37566179

773.

Xanthatin suppresses pancreatic cancer cell growth via the ROS/RBL1 signaling pathway: In vitro and in vivo insights.

Xanthatin, a compound from Xanthium strumarium, has shown inhibitory effects on various cancers. Its impact on pancreatic cancer needs further research.

Cancer Xanthium strumarium

Geng Y et al (2023).; Phytomedicine.
DOI:: 10.1016/j.phymed.2023.155004
PubMed:: 37562091

774.

Phytofabrication of silver nanoparticles using Averrhoa bilimbi leaf extract for anticancer activity.

Green leaf extract was used to make stable silver nanoparticles. These nanoparticles showed effective cytotoxicity against lung and breast cancer cells, making them potential anticancer agents.

Cancer Averrhoa bilimbi

Hublikar LV, Ganachari SV and Patil VB (2023).; Nanoscale Adv.
DOI:: 10.1039/d3na00313b
PubMed:: 37560425

775.

Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.

Picropodophyllin (PPP), extracted from Dysosma versipellis, inhibits gastric cancer (GC) cell proliferation by inducing apoptosis. PPP blocks the AKT/mTOR signaling pathway by targeting heat shock protein 90 (HSP90), making it a potential therapeutic compound for GC treatment.

Cancer Gastroenterology Dysosma versipellis

Li X et al (2023).; Phytother Res.
DOI:: 10.1002/ptr.7943
PubMed:: 37559472

776.

Curcuminoids as cell signaling pathway modulators: A potential strategy for cancer prevention.

Curcuminoids derived from turmeric have shown potential in inhibiting cancer progression and modulating signal transduction pathways, miRNA expression, and biomarkers. Strategies for enhancing bioavailability are explored.

Cancer Curcuma longa

Noor A et al (2023).; Curr Med Chem.
DOI:: 10.2174/0929867331666230809100335
PubMed:: 37559247