Cancer Studies

Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.

Scientists studied Solanum nigrum L., a plant used to treat tumors, and found that its steroidal alkaloid Solasonin (SS) has anti-colorectal cancer (CRC) activity. SS induced apoptosis and cell cycle arrest in CRC cells by downregulating HDAC and increasing P53 acetylation. SS could effectively inhibit CRC growth, making it a potential treatment option.

CancerGastroenterology Solanum nigrum
Lan X et al (2023).
Molecules.
DOI:
10.3390/molecules28186649
PubMed:
37764423

Piperlongumine Induces Apoptosis and Cytoprotective Autophagy via the MAPK Signaling Pathway in Human Oral Cancer Cells.

This study investigated the anticancer effects of piperlongumine (PL) in human oral cancer cell lines. PL inhibits cell proliferation by inducing apoptosis and autophagy, and combining an autophagy inhibitor with PL treatment can have effective anticancer properties.

CancerImmunology Piper longum
Choi EY et al (2023).
Biomedicines.
DOI:
10.3390/biomedicines11092442
PubMed:
37760883

Licochalcone A induces G2/M phase arrest and apoptosis via regulating p53 pathways in esophageal cancer: In-vitro and in-vivo study.

Licochalcone A (LCA), a compound from Glycyrrhiza uralensis, shows potential for treating esophageal cancer (EC). LCA inhibited EC cell proliferation, migration, and invasion while inducing apoptosis and cell cycle arrest. LCA also inhibited tumor growth in mice without major side effects. LCA can be a promising therapy for EC by regulating the p53 pathway.

Cancer Glycyrrhiza uralensis
Liu J et al (2023).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2023.176080
PubMed:
37758012

Investigation of the anti-cancer potential of epoxyazadiradione in neuroblastoma: experimental assays and molecular analysis.

The researchers studied a compound called EAD from seed and found that it effectively suppressed the growth of neuroblastoma, a childhood tumor. EAD inhibited certain proteins (Enolase1 and HSP90) involved in neuroblastoma development, suggesting it could be a potential treatment.

Cancer Azadirachta indica
Chandel S et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2262593
PubMed:
37753734

Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms.

Tldr: Withaferin A (WA), a compound from a dietary supplement, shows significant anti-tumor effects by inhibiting cell cycle, apoptosis, metastasis, and angiogenesis. It has potential targets for cancer treatment, but toxicity and bioavailability issues need addressing. Further research on its exact mechanism is crucial.

Cancer Withania somnifera
Xing Z et al (2023).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S422512
PubMed:
37753228

Unleashing the Potential of Benincasa hispida Peel Extract: Synthesizing Selenium Nanoparticles with Remarkable Antibacterial and Anticancer Properties.

Researchers used ash gourd extract to synthesize selenium nanoparticles with unique properties. These nanoparticles have antibacterial effectiveness, spherical shape, and potential for fighting cancer. They are also non-toxic to human osteoblasts, making them promising for medical applications.

Cancer Benincasa hispida
Khan S et al (2023).
Mol Biotechnol.
DOI:
10.1007/s12033-023-00884-y
PubMed:
37752300

Polyphyllin I induces ferroptosis in castration-resistant prostate cancer cells through the ERK/DNMT1/ACSL4 axis.

The researchers studied the effects of a compound called Polyphyllin I (PPI) on castration-resistant prostate cancer cells. PPI showed potential as a treatment and the study explored its mechanism of action.

Cancer Paris polyphylla
Zou P et al (2023).
Prostate.
DOI:
10.1002/pros.24626
PubMed:
37750290

Identification of phenolic compounds from inflorescences of non-psychoactive Cannabis sativa L. by UHPLC-HRMS and in vitro assessment of the antiproliferative activity against colorectal cancer.

Researchers obtained an enriched fraction of polyphenols from non-psychoactive hemp and evaluated its potential as a therapeutic product against colorectal cancer. Promising antiproliferative activity was observed, suggesting further investigation is warranted.

CancerGastroenterologyPhytochemistry Cannabis sativa
Caroli C et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115723
PubMed:
37748359
1 77 86 87 88 97 258