Identification of bioactive compounds from Vaccinium vitis-idaea L. (Lingonberry) as inhibitors for treating KRAS-associated cancer: a computational approach.

Study finds Lingonberry plant compounds with potential to treat KRAS-associated lung cancer, including arbutin, (+)-catechin, and sinapic acid.

Ilesanmi A et al (2023).

In Silico Pharmacol.

DOI:

10.1007/s40203-023-00165-1

PubMed:

37915613

Inhibitory effect of liriopesides B in combination with gemcitabine on human pancreatic cancer cells.

Hong P et al (2024).

Bioorg Chem.

DOI:

10.1016/j.bioorg.2023.106937

PubMed:

37913583

Evaluation of Enhanced Cytotoxicity Effect of Repurposed Drug Simvastatin/ Thymoquinone Combination against Breast Cancer Cell Line.

Repurposing drugs for cancer treatment is growing in importance for drug discovery. It could lead to more efficient development of new treatments and potentially save time and resources in the fight against cancer.

Kumari P and Dang S (2023).

Cardiovasc Hematol Agents Med Chem.

DOI:

10.2174/0118715257259037231012182741

PubMed:

37907488

Mechanism of Paris polyphylla saponin II inducing autophagic to inhibit angiogenesis of cervical cancer.

Paris polyphylla saponin II (PPII) inhibits tumor angiogenesis, but its mechanism is unknown. This study found that PPII increases autophagy in HUVEC cells through the PI3K/AKT/mTOR pathway, thereby inhibiting Hela cell proliferation, invasion, and migration. Care because PPII could potentially be used to treat cervical cancer.

Cheng H et al (2023).

Naunyn Schmiedebergs Arch Pharmacol.

DOI:

10.1007/s00210-023-02794-x

PubMed:

37906274

Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway.

This study found that the natural compound wogonin can reverse radioresistance in breast cancer cells by inhibiting the Nrf2/HIF-1 pathway. This offers potential strategies to improve the effectiveness of radiotherapy in breast cancer treatment.

Wang T et al (2023).

Am J Chin Med.

DOI:

10.1142/S0192415X23500969

PubMed:

37903716

Cytotoxic Activity of Hypericum triquetrifolium Turra Methanolic Extract Against Cancer Cell Lines.

Hypericum triquetrifolium Turra has been used in traditional medicine in the Mediterranean region. Despite extensive research on its essential oils, little is known about other potential health benefits.

Al-Anee RS, Al-Ani EH and Mousa ZS (2023).

Asian Pac J Cancer Prev.

DOI:

10.31557/APJCP.2023.24.10.3599

PubMed:

37898868

Optimized bilosome-based nanoparticles enhance cytotoxic and pro-apoptotic activity of costunolide in LS174T colon cancer cells.

Researchers developed a nanoformulation of costunolide (COST) to improve its anti-proliferative effects in colon cancer cells. The optimized formulation showed increased cytotoxicity, enhanced apoptosis, and altered gene expression compared to raw COST, making it more effective in killing cancer cells.

Alamoudi AJ et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.115757

PubMed:

37897972

Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives.

Scientists investigated the anticancer effects of rhein, a natural agent, in liver cancer. They identified its molecular targets and examined whether it can work with artemisinin derivatives to inhibit the disease. This research may lead to improved therapies for liver cancer.

Wang J et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155156

PubMed:

37897861