High-throughput screening of ancient forest plant extracts shows cytotoxicity towards triple-negative breast cancer.

Scientists screened plant extracts from Chinese forests and found Amur honeysuckle and Nigaki to be effective against triple-negative breast cancer. These extracts reduced tumor weight by 60.5% and killed 70% of breast cancer cells, suggesting their potential as new cancer treatments.

Li Y et al (2023).

Environ Int.

DOI:

10.1016/j.envint.2023.108279

PubMed:

37924601

Clinical characteristics and therapeutic behavior of breast cancer patients using mistletoe therapy consulting a clinic offering integrative oncology: a registry data analysis.

Study investigated treatment patterns of breast cancer patients in Switzerland using complementary and alternative medicine. Understanding this can improve integrative oncology care in the country.

Krüerke D, Schenker M and Matter-Walstra K (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-04219-x

PubMed:

37924102

Acetylation of MOB1 mediates polyphyllin II-reduced lysosome biogenesis in breast cancer by promoting the cytoplasmic retention of the YAP/TFEB coactivator complex.

Researchers investigated the effects of Polyphyllin II (PPII), a compound from Paris polyphylla, on autophagy-lysosome dysfunction in cancer. PPII showed potential antitumor activity, making it relevant for potential therapeutic interventions.

Ren Y et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155152

PubMed:

37922793

Silencing E6/E7 Oncoproteins in SiHa Cells Treated with siRNAs and Oroxylum indicum Extracts Induced Apoptosis by Upregulating p53/pRb Pathways.

Sisin NNT et al (2023).

Appl Biochem Biotechnol.

DOI:

10.1007/s12010-023-04762-w

PubMed:

37922032

Exploring the mechanism of resistance to vincristine in breast cancer cells using transcriptome sequencing technology.

Scientists investigated the development of resistance to vincristine (VCR), a chemotherapy drug used for breast cancer treatment. By analyzing gene expression and splicing events, they identified changes in the VCR-resistant breast cancer cell line. This study lays the foundation for understanding VCR resistance and developing potential treatments.

Chen Y et al (2023).

Oncol Lett.

DOI:

10.3892/ol.2023.14089

PubMed:

37920438

The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study.

The study found that Ganoderma lucidum polysaccharide, when used in combination with Docetaxel and Flutamide, significantly enhanced apoptosis, reduced cell migration and colonization, and decreased the expression of prostate cancer biomarkers. This suggests that Ganoderma lucidum polysaccharide could be a new potential therapy for prostate cancer.

Rahimnia R et al (2023).

Sci Rep.

DOI:

10.1038/s41598-023-46118-8

PubMed:

37919464

Green synthesized silver nanoparticles using the plant-based reducing agent Matricaria chamomilla induce cell death in colorectal cancer cells.

Researchers used chamomile to synthesize silver nanoparticles (SNs) with anticancer properties, providing a safe and natural alternative to chemotherapy. This could potentially reduce side effects and offer a more affordable and eco-friendly treatment option for cancer.

Abdellatif AAH et al (2023).

Eur Rev Med Pharmacol Sci.

DOI:

10.26355/eurrev_202310_34191

PubMed:

37916381

The prevalence and pattern of complementary and alternative medicine use among cancer patients in a tertiary oncology center: a cross-sectional study.

CAM is commonly used to treat cancer, but patients mistakenly believe it is safer than conventional treatments. Important to consider patient beliefs and educate them on evidence-based treatments to ensure best care.

Almouaalamy NA et al (2023).

Ann Med Surg (Lond).

DOI:

10.1097/MS9.0000000000001315

PubMed:

37915654