Thymoquinone-loaded lipid nanocapsules with promising anticancer activity for colorectal cancer.

Thymoquinone (TQ), found in black seeds, was tested as a treatment for colorectal cancer in mice. When encapsulated in lipid nanocapsules, TQ effectively reduced tumor size and induced tumor cell death, making it a potential anticancer agent for colorectal cancer treatment.

Selmi M et al (2023).

Nanoscale Adv.

DOI:

10.1039/d3na00445g

PubMed:

37767034

Evaluation of Anticancer Activity of 76 Plant Species Collected in Andalusia (Spain) against Lung Cancer Cells.

Scientists screened 76 plant species from Andalusia, Spain for potential anticancer activity. Extracts from certain plants showed selective cytotoxicity against lung cancer cells, including the flower extract which outperformed standard drugs. This study suggests that these plants could be sources of new anticancer compounds.

Jiménez-González V et al (2023).

Plants (Basel).

DOI:

10.3390/plants12183275

PubMed:

37765439

Antioxidant and Antiproliferative Activities of Phenolic Extracts of Eriobotrya japonica (Thunb.) Lindl. Fruits and Leaves.

Scientists studied the phenolic compounds in loquat fruits and leaves from Tuscany, Italy. The leaf extract showed higher antioxidant and anticancer potential than the fruit extract, and both can be used as a source of antioxidants in food or cosmetics/pharmaceuticals.

Pawłowska AM et al (2023).

Plants (Basel).

DOI:

10.3390/plants12183221

PubMed:

37765385

Syzygium cumini (L.) Extract-Derived Green Titanium Dioxide Nanoparticles Induce Caspase-Dependent Apoptosis in Hepatic Cancer Cells.

Green-synthesized titanium dioxide nanoparticles (TiO NPs) from seed extract were studied. Characterized by various techniques, the TiO NPs showed promising anticancer effects, inhibiting liver cancer cell growth and inducing apoptosis. This suggests potential for TiO NPs in cancer treatment.

Rayzah M et al (2023).

Plants (Basel).

DOI:

10.3390/plants12183174

PubMed:

37765338

Piper nigrum Extract Inhibits the Growth of Human Colorectal Cancer HT-29 Cells by Inducing p53-Mediated Apoptosis.

Researchers investigated the effect of a plant extract (PNE) on colorectal cancer (CRC) cells. PNE was found to inhibit cell proliferation, induce apoptosis, and inhibit tumor growth by regulating p53 and activating the caspase-3 pathway. PNE could be a potential natural anti-CRC drug candidate.

Wu R et al (2023).

Pharmaceuticals (Basel).

DOI:

10.3390/ph16091325

PubMed:

37765133

The Antitumor Activity of Piplartine: A Review.

Piplartine, a compound found in Linn, has shown promising antitumor activity against different types of cancer. Further research and development of synthetic derivatives could lead to new and improved anticancer drugs.

Duarte ABS et al (2023).

Pharmaceuticals (Basel).

DOI:

10.3390/ph16091246

PubMed:

37765054

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells.

Hibiscus anthocyanin-rich extracts induce apoptosis in colorectal cancer cells by activating AMPK and Fas-mediated pathways, leading to caspase-3 cleavage and cell death. This highlights the potential of these extracts for cancer treatment.

Tsai MC et al (2023).

Nutrients.

DOI:

10.3390/nu15183972

PubMed:

37764756

Molecular Docking and Molecular Dynamics Studies Reveal the Anticancer Potential of Medicinal-Plant-Derived Lignans as MDM2-P53 Interaction Inhibitors.

Shoaib TH et al (2023).

Molecules.

DOI:

10.3390/molecules28186665

PubMed:

37764441