Cancer Studies

Toxicity and antitumor activity of the water-soluble lectin from Moringa oleifera Lam. Seeds (WSMoL) in sarcoma 180-bearing mice.

This study investigates the toxicity and antitumor activity of WSMoL, a lectin from Moringa oleifera seeds. Acute toxicity was seen at high doses, but no significant harm was observed at lower doses. WSMoL also reduced tumor weight and enhanced immune function in the tumor environment. This suggests that WSMoL may have potential as an antitumor agent.

Cancer Moringa oleifera
Brito JS et al (2023).
Toxicon.
DOI:
10.1016/j.toxicon.2023.107306
PubMed:
37778740

The Extract of Pinellia Ternata-Induced Apoptosis of Leukemia Cells by Regulating the Expression of Bax, Bcl-2 and Caspase-3 Protein Expression in Mice.

Pinellia ternata extract was tested on leukemia cells using various techniques. Results showed that the extract can decrease cell proliferation and promote apoptosis, making it a potential new therapy for leukemia.

Cancer Pinellia ternata
Li ZF et al (2023).
Transplant Proc.
DOI:
10.1016/j.transproceed.2023.08.015
PubMed:
37777366

Antioxidative and ROS-dependent apoptotic effects of Cuscuta reflexa Roxb. stem against human lung cancer: network pharmacology and in vitro experimental validation.

Study explores stem extract as potential lung cancer treatment with antioxidant and apoptotic properties. Extract showed cytotoxic activity against cancer cells, increasing ROS generation and mitochondrial depolarization. Promising therapeutic strategy.

Cancer Cuscuta reflexa
Elasbali AM et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2263889
PubMed:
37776015

Solanum nigrum Linn.: Advances in anti-cancer activity and mechanism in digestive system tumors.

S. nigrum Linn., a traditional Chinese herb, has proven anti-cancer activity against digestive system tumors. Its components include solanine, solasonine, and solamargine. The herb induces apoptosis, cell cycle arrest, autophagy, and more, making it a potential standardized anti-tumor drug for further clinical trials.

Cancer Solanum nigrum
Pei H et al (2023).
Med Oncol.
DOI:
10.1007/s12032-023-02167-7
PubMed:
37775552

New insights into the cytotoxic effects of Thymus vulgaris essential oil on the human triple-negative breast cancer cell line MDA-MB-231.

Thyme essential oil (EO) inhibited the growth and spread of triple-negative breast cancer cells. It induced apoptosis, increased oxidative stress, and activated Nrf2 pathway. Use of thyme EO may be beneficial for treating triple-negative breast cancer.

CancerPhytochemistry Thymus vulgaris
Benedetti S et al (2023).
Toxicol In Vitro.
DOI:
10.1016/j.tiv.2023.105705
PubMed:
37775061

Lycorine inhibits pancreatic cancer cell growth and neovascularization by inducing Notch1 degradation and downregulating key vasculogenic genes.

Lycorine, a compound from Lycoris radiata herb, inhibits pancreatic cancer cell growth and reduces migration, invasion, neovascularization, and drug resistance, potentially serving as a treatment for pancreatic cancer.

CancerGenetics Lycoris radiata
Qi J et al (2023).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2023.115833
PubMed:
37769714

Green synthesis, characterization of melatonin-like drug bioconjugated CoS quantum dots and its antiproliferative effect on different cancer cells.

Scientists investigated the combination of melatonin (an anticancer compound) with quantum dots in cancer treatment. This study pioneers the examination of ramelteon bioconjugation to quantum dots, offering new insights into using melatonin derivatives for cancer therapy.

Cancer Punica granatum
Balpınar Ö, Nadaroğlu H and Hacımüftüoğlu A (2023).
Mol Biol Rep.
DOI:
10.1007/s11033-023-08817-3
PubMed:
37768465

Green synthesis, antibacterial and antifungal evaluation of new thiazolidine-2,4-dione derivatives: molecular dynamic simulation, POM study and identification of antitumor pharmacophore sites.

Thiazolidine-2,4-dione derivatives with certain substituents showed strong antibacterial and antifungal activity, as well as potential as a targeted drug against multiple pathogens. Pharmacokinetics studies indicated drug-likeness and non-toxicity, contributing to the development of new drug candidates.

AntimicrobialCancer Lycopodium sp.
Ahmed S et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2258404
PubMed:
37768136
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