Identification of Differentially Expressed Genes in Human Colorectal Cancer Using RNASeq Data Validated on the Molecular Level with Real-Time PCR.

Bioinformatics tools identified early detection biomarkers for colorectal cancer and explored plant extract as a chemotherapy alternative. Three diagnostic markers identified, with positive trends in gene expression and therapeutic value. Further trials required. Precise and robust analysis workflow valuable for CRC diagnosis and treatment decisions.

Elsayed AMA et al (2023).

Biochem Genet.

DOI:

10.1007/s10528-023-10593-5

PubMed:

38097858

Bio-valorization of Tagetes floral waste extract in fabrication of self-healing Schiff-base nanocomposite hydrogels for colon cancer remedy.

Floral waste from marigold flowers is used to create a hydrogel that has self-healing ability, enhanced antioxidant and anti-inflammatory properties, and controlled release of a drug for colorectal cancer treatment. This study highlights the potential of using floral waste for colon cancer remedy.

Dalei G et al (2023).

Environ Sci Pollut Res Int.

DOI:

10.1007/s11356-023-31392-w

PubMed:

38097839

Divergent synthesis of fractionated Cannabis sativa extract led to multiple cannabinoids C-&O-glycosides with anti-proliferative/anti-metastatic properties.

Nalli Y et al (2024).

Bioorg Chem.

DOI:

10.1016/j.bioorg.2023.107030

PubMed:

38091718

Reresearch progress on the antitumor effects and mechanisms by active ingredients in Houttuynia cordata.

Wu X and Li H (2023).

Asian J Surg.

DOI:

10.1016/j.asjsur.2023.12.036

PubMed:

38087694

Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer.

Thymoquinone (TQ) from Nigella sativa has anti-cancer properties against colorectal cancer. It can enhance existing cancer treatments and reduce adverse effects. More research is needed to understand its molecular targets and improve its clinical usefulness in overcoming drug resistance and obstacles in chemotherapy and radiotherapy.

Sheikhnia F et al (2023).

Cancer Cell Int.

DOI:

10.1186/s12935-023-03174-4

PubMed:

38087345

Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway.

Cepharanthine (CEP) derived from Stephania Cephalantha Hayata inhibits gastric cancer cell growth by inducing apoptosis and cell cycle arrest. It also regulates oxidative stress and alters energy metabolism, suggesting potential for gastric cancer treatment.

Lu YY et al (2023).

Cell Death Discov.

DOI:

10.1038/s41420-023-01752-z

PubMed:

38086844

Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer - An Overview.

CAM options such as medical cannabis, plants, fungi, and herbal formulas, particularly from traditional Chinese or Japanese medicine, show promise in treating pancreatic cancer. They may improve quality of life and be a useful addition to conventional therapy.

Tarasiuk A, Mirocha G and Fichna J (2023).

Curr Treat Options Oncol.

DOI:

10.1007/s11864-023-01146-4

PubMed:

38079061

Cancer chemoprevention with PV-1, a novel Prunella vulgaris-containing herbal mixture that remodels the tumor immune microenvironment in mice.

PV-1, a herbal mixture, showed immune-stimulatory and anti-inflammatory effects. It inhibited lung and oral cancer development in mouse models, increased CD8+ TILs, suppressed g-MDSCs, and improved anti-cancer immunotherapy. PV-1 has potential for cancer chemoprevention and immune remodeling.

Zhang Q et al (2023).

Front Immunol.

DOI:

10.3389/fimmu.2023.1196434

PubMed:

38077406