Cancer Studies

Polyphyllin VII induces autophagy-dependent ferroptosis in human gastric cancer through targeting T-lymphokine-activated killer cell-originated protein kinase.

Polyphyllin VII (PPVII), a compound found in Paris polyphylla, can inhibit gastric cancer (GC) by inducing autophagy-mediated ferroptosis. PPVII activates the ULK1 pathway, inhibits the activity of the protein TOPK, and stabilizes its inactive form, suggesting PPVII could be a potential treatment for GC.

CancerGastroenterology Paris polyphylla
Xiang Y et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7986
PubMed:
37632389

Cytotoxic Screening and Enhanced Anticancer Activity of Lippia alba and Clinopodium nepeta Essential Oils-Loaded Biocompatible Lipid Nanoparticles against Lung and Colon Cancer Cells.

This study evaluated the cytotoxic activity of plant and herbal essential oils (EOs) against lung and colon cancer cells. The most potent EOs were encapsulated into solid lipid nanoparticles (SLN) to enhance their anticancer activity. SLN/CnEO was found to be safe and significantly increased cancer cell death and inhibition of cell migration.

CancerGastroenterology Eucalyptus globulusMentha arvensisMentha piperita
Rodenak-Kladniew B et al (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15082045
PubMed:
37631258

An In Vitro Evaluation and Network Pharmacology Analysis of Prospective Anti-Prostate Cancer Activity from Perilla frutescens.

L. Britt. leaf extracts contain rosmarinic acid, which exhibits potent cytotoxic effects on prostate cancer cells and interacts with multiple targets and pathways involved in prostate cancer. These findings suggest a potential use of L. Britt. leaves or their metabolites in prostate cancer treatment and prevention.

Cancer Perilla frutescens
Garcia PJB et al (2023).
Plants (Basel).
DOI:
10.3390/plants12163006
PubMed:
37631218

Ethnomedicinal Uses, Phytochemistry, and Anticancer Potentials of African Medicinal Fruits: A Comprehensive Review.

This review explores the use of African fruits in traditional medicine and their potential as anticancer agents. It emphasizes the importance of further research and suggests that these fruits could provide valuable phytochemicals for anticancer studies.

CancerEthnobotanyPhytochemistry Abelmoschus esculentusAnnona muricataKigelia africanaPersea americanaSclerocarya birreaSyzygium cuminiTribulus terrestrisWithania somniferaXanthium strumarium
Fakudze NT et al (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16081117
PubMed:
37631032

In Silico Analysis of the Effect of Hydrastis canadensis on Controlling Breast Cancer.

Researchers studied the effects of Hydrastis Canadensis (Goldenseal) on hormone-independent breast cancer using computational techniques. Canadaline and Riboflavin were found to effectively interact with target proteins, making Hydrastis Canadensis a potential treatment for hormone-independent and some hormone-dependent breast cancers.

Cancer Hydrastis canadensis
Vyshnavi Am H et al (2023).
Medicina (Kaunas).
DOI:
10.3390/medicina59081412
PubMed:
37629702

Petiveria alliacea Reduces Tumor Burden and Metastasis and Regulates the Peripheral Immune Response in a Murine Myeloid Leukemia Model.

Alcoholic extract from Esperanza plant shows promising antitumor effects on AML by reducing cell proliferation, improving blood parameters, reducing tumor infiltration, and increasing cytokine production. Potential safer and more effective therapeutic option.

Cancer Petiveria alliacea
Murillo N et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241612972
PubMed:
37629156

Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy.

Scientists explore the anticancer potential of mangiferin, derived from the Mangifera indica plant, using nanoparticle carriers to overcome its delivery challenges. Deep-learning approaches are also discussed for pharmacokinetic issues.

Cancer Mangifera indica
Sarfraz M et al (2023).
Cancers (Basel).
DOI:
10.3390/cancers15164194
PubMed:
37627222

Green synthesized silver nanoparticles mediated by Fusarium nygamai isolate AJTYC1: characterizations, antioxidant, antimicrobial, anticancer, and photocatalytic activities and cytogenetic effects.

Scientists used a green method to produce silver nanoparticles (AgNPs) and found that they have various promising properties. AgNPs showed antioxidant, antibacterial, antifungal, and anticancer activity, as well as the ability to decolorize dyes. This method could contribute to disease treatment and reduce wastewater dye contamination.

AntimicrobialCancerImmunology Allium cepa
El-Ansary AE et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-29414-8
PubMed:
37626196
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