The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis.

Gymnema Sylvestre (GS) supplementation may improve cardiovascular risk factors including lipid profile, glycemic control, blood pressure, and anthropometric indices, according to a study. However, more research is needed due to limitations in study quality and heterogeneity.

Zamani M et al (2023).

Phytother Res.

DOI:

10.1002/ptr.7585

PubMed:

36580574

Identification of ligustrazine-based analogs of piperlongumine as potential anti-ischemic stroke agents.

Researchers synthesized four analogs of piperlongumine, an alkaloid found in Piper longum, and tested their anti-platelet aggregation activity. Compound 8 showed the strongest activity, so it was studied further and found to have good binding affinity to stroke-related protein targets. Animal experiments showed that compound 8 could significantly improve brain tissue damage after ischemia, potentially reducing injury from ischemic stroke by inhibiting apoptosis and structural disorders. This suggests piperlongumine analogs could be developed into treatments for ischemic stroke.

Lijuan T et al (2023).

Fitoterapia.

DOI:

10.1016/j.fitote.2022.105398

PubMed:

36563762

Ligustroflavone exerts neuroprotective activity through suppression of NLRP1 inflammasome in ischaemic stroke mice.

Researchers investigated using LIG, a compound derived from an herbal plant, as a potential treatment for ischemic stroke. They established an ischaemic stroke model in mice and used various tests to assess neurological deficits. Treatment with LIG showed significant anti-inflammatory and neuroprotective activity by minimizing impairment of neurological function, blocking neuronal damage, and attenuating upregulation of inflammatory cytokines. Overall, the findings suggest the potential of LIG as a treatment for stroke by inhibiting NLRP1 inflammasome and reducing inflammation.

Bi F et al (2022).

Exp Ther Med.

DOI:

10.3892/etm.2022.11707

PubMed:

36561613

Er-xian ameliorates myocardial ischemia-reperfusion injury in rats through RISK pathway involving estrogen receptors.

Qiang M et al (2022).

Chin J Nat Med.

DOI:

10.1016/S1875-5364(22)60213-9

PubMed:

36549804

Andrographolide contributes to the attenuation of cardiac hypertrophy by suppressing endoplasmic reticulum stress.

Tian Q et al (2023).

Pharm Biol.

DOI:

10.1080/13880209.2022.2157021

PubMed:

36548192

Network pharmacology approach and experimental verification of Dan-Shen Decoction in the treatment of ischemic heart disease.

Gong D et al (2023).

Pharm Biol.

DOI:

10.1080/13880209.2022.2152059

PubMed:

36546685

The mechanism of Renshen-Fuzi herb pair for treating heart failure-Integrating a cardiovascular pharmacological assessment with serum metabolomics.

Chen X et al (2022).

Front Pharmacol.

DOI:

10.3389/fphar.2022.995796

PubMed:

36545315

Assessment of hypolipidemic and anti-inflammatory properties of walnut (Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR-1339-induced hyperlipidemia in rat kidney, liver, and heart.

Palabıyık E et al (2023).

J Mol Recognit.

DOI:

10.1002/jmr.3004

PubMed:

36537558