Cardiology Studies

Ex vivo and in vivo studies of Viola tricolor Linn. as potential cardio protective and hypotensive agent: Inhibition of voltage-gated Ca(++) ion channels.

Viola tricolor Linn. is a traditional medicine used for its cardio-protective and anti-hypertensive effects. The study aimed to evaluate its effects in in vitro and in vivo studies. The crude extract and its fractions were tested on rabbit atria and aorta, and the blood pressure was measured in normotensive ketamine-diazepam anesthetized rats. The results show that Viola tricolor L. has cardio-relaxant, vasorelaxant, hypotensive, and cardioprotective effects mediated through Voltage dependent L-type calcium channels blockage. The study suggests that Viola tricolor L. can be used to treat cardiovascular disorders.

Saqib F et al (2020).
FASEB J.
PubMed:
32475023