Covid-19 Studies

Unraveling the Potential Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Mechanisms of Ginger by Computational Target Fishing.

This study identified 20 active compounds in ginger that target 18 human proteins and 12 SARS-CoV-2 proteins, suggesting its potential as a treatment for COVID-19. SIGMAR1 and histone deacetylase 2 could be important proteins in this process.

COVID-19 Zingiber officinale
Chen S and Zhang L (2023).
J Med Food.
DOI:
10.1089/jmf.2023.K.0027
PubMed:
37682285

In silico guided screening of active components of C. lanceolata as 3-chymotrypsin-like protease inhibitors of novel coronavirus.

Researchers conducted computational screening of phytoconstituents from a specific plant to identify potential antiviral hit candidates against 3CLpro, a target for COVID-19 treatment. Stigmasterol showed the highest binding affinity and exhibited stable interactions. This study suggests as a potential drug candidate for further development against the virus.

COVID-19 Codonopsis lanceolata
Sharma G et al (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03745-2
PubMed:
37663751

Lavender (Lavandula angustifolia) syrup as an adjunct to standard care in patients with mild to moderate COVID-19: An open-label, randomized, controlled clinical trial.

This study investigated the effectiveness of lavender syrup, alongside standard care, for patients with mild to moderate COVID-19 symptoms. Understanding its potential benefits can help scientists make informed decisions regarding treatment options for COVID-19 patients.

COVID-19 Lavandula angustifolia
Qaraaty M et al (2023).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2022.21606
PubMed:
37663382

Cheminformatics and systems pharmacology approaches to unveil the potential plant bioactives to combat COVID-19.

Scientists used systems pharmacology and cheminformatics to identify 13 bioactive compounds from plants that have potential to counteract COVID-19. These compounds target specific genes related to the virus and showed better efficacy than current drugs. This study supports the use of natural products in developing new treatments for the disease.

COVID-19 Cinnamomum verum
Muralitharan D, Varadharajan V and Venkidasamy B (2023).
J Mol Recognit.
DOI:
10.1002/jmr.3055
PubMed:
37658788

Evaluation of berberine pellet effect on clinical recovery time in COVID-19 outpatients: A pilot clinical trial.

Berberine, a medicinal compound with analgesic, anti-asthmatic, anti-inflammatory, and antiviral properties, was studied for its effect on COVID-19 outpatients. Understanding its impact could provide insights into treating respiratory distress syndrome caused by severe COVID-19.

COVID-19 Berberis vulgaris
Omidvar Tehrani S et al (2023).
Avicenna J Phytomed.
DOI:
10.22038/AJP.2022.21539
PubMed:
37654997

Glycyrrhiza glabra L. Extracts and Other Therapeutics against SARS-CoV-2 in Central Eurasia: Available but Overlooked.

Favipiravir didn't work against SARS-CoV-2, but Cridanimod showed promising results in suppressing its replication. Tilorone stimulated replication, while licorice extract inhibited replication but with low activity. Cridanimod is a potential candidate for clinical trials, while licorice extract could be further developed as a safe adjunctive therapy.

COVID-19 Glycyrrhiza glabra
Zhurinov MZ et al (2023).
Molecules.
DOI:
10.3390/molecules28166142
PubMed:
37630394

Efficacy of Andrographis paniculata extract treatment in mild to moderate COVID-19 patients being treated with favipiravir: A double-blind, randomized, placebo-controlled study (APFaVi trial).

Favipiravir is commonly used to treat COVID-19, but its effectiveness is uncertain. Andrographis paniculata extract has antiviral properties and could be a promising treatment for early-stage COVID-19.

COVID-19 Andrographis paniculata
Siripongboonsitti T et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155018
PubMed:
37625206

Synthesis and Characterisation of Chickpea Peptides-Zinc Chelates Having ACE2 Inhibitory Activity.

Scientists discovered that certain peptides in chickpea protein hydrolysates have a strong ability to bind with zinc ions. One peptide, HKERVQLHIIPTAVGK, was especially effective at binding zinc and showed promising effects in inhibiting ACE2. This study has important implications for understanding zinc's bioavailability and potential health benefits.

COVID-19 Cicer arietinum
Mukhamedov N et al (2023).
Protein J.
DOI:
10.1007/s10930-023-10133-5
PubMed:
37610664
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