Covid-19 Studies

The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression.

Researchers investigated the potential of herbal medicines for treating COVID-19. They found that certain herbs have shown effectiveness as immunomodulators, anti-inflammatories, antioxidants, and antimicrobials.

COVID-19 Nigella sativa
Komariah M et al (2023).
Ther Clin Risk Manag.
DOI:
10.2147/TCRM.S405507
PubMed:
37484695

Ashwagandha (Withania somnifera) and Shunthi (Zingiber officinale) in mild and moderate COVID-19: An open-label randomized controlled exploratory trial.

Ayurveda treatments used in India during COVID-19 showed positive outcomes in aiding early recovery from the virus.

COVID-19 Withania somniferaZingiber officinale
Singh H et al (2023).
Complement Ther Med.
DOI:
10.1016/j.ctim.2023.102966
PubMed:
37482107

Four new stilbenes and one new flavonoid with potential antibacterial and anti-SARS-CoV-2 activity from Cajanus cajan.

New compounds from pigeon pea leaves showed potent antibacterial activity and potential anti-SARS-CoV-2 main protease activity, making them promising candidates for antibacterial and anti-COVID-19 drug development.

COVID-19Phytochemistry Cajanus cajan
Chen JY et al (2023).
J Nat Med.
DOI:
10.1007/s11418-023-01727-5
PubMed:
37462863

Inhibition of Cysteine Proteases via Thiol-Michael Addition Explains the Anti-SARS-CoV-2 and Bioactive Properties of Arteannuin B.

In this study, scientists isolated a derivative of arteannuin B from a plant extract. This derivative inhibited the activity of the SARS-CoV-2 virus and a cancer enzyme. Understanding these activities can help develop treatments for malaria, COVID-19, and cancer.

COVID-19 Artemisia annua
Varela K et al (2023).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.2c01146
PubMed:
37458412

Auraptene Has Antiviral Activity against Human Coronavirus OC43 in MRC-5 Cells.

Auraptene, found in fruits, has various medical properties (anticancer, antioxidant, etc.). It effectively inhibits HCoV-OC43, reducing viral RNA levels and protein expression, making it a potential therapeutic agent for human coronavirus.

AntimicrobialCOVID-19 Citrus trifoliata
Min JS, Jin YH and Kwon S (2023).
Nutrients.
DOI:
10.3390/nu15132960
PubMed:
37447286

An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: Insights into molecular mechanisms.

Baicalein and baicalin, compounds from plants, show potential as drugs to treat COVID-19. They exhibit antiviral and anti-inflammatory properties, suppressing viral infection and reducing organ damage. More research is needed to determine their safety and effectiveness in patients. This offers hope for new antiviral treatments.

COVID-19Immunology Scutellaria baicalensis
Dinda B et al (2023).
Eur J Med Chem.
DOI:
10.1016/j.ejmech.2023.115629
PubMed:
37437351

The sesquiterpenes with the COVID-19 M(pro) inhibitory activity from the Carpesium abrotanoides L.

New compounds, including claroguaiane A, were found in a study on L. plant. These compounds were tested for COVID-19 inhibitory activity, with one showing potent effects (IC value of 16.58 µM) and another showing moderate effects (IC value of 36.81 μM).

COVID-19 Carpesium abrotanoides
Fan YW et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2230609
PubMed:
37403616

Antiviral Activity of Cannabidiolic Acid and Its Methyl Ester against SARS-CoV-2.

Cannabinoids from L. show antiviral effects against SARS-CoV-2 variants. Cannabidiolic acid (CBDA) is the most active compound, but its instability led researchers to develop a more effective CBDA methyl ester. It effectively neutralized all variants and could be a potential COVID-19 drug.

AntimicrobialCOVID-19 Cannabis sativa
Tamburello M et al (2023).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.3c00111
PubMed:
37402317
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