Covid-19 Studies

In Vitro and In Vivo Therapeutic Potential of 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea on Cells and K18-hACE2 Mice Infected with SARS-CoV-2.

Researchers found that the alkaloid mixture DTBN extracted from nuphar luteum is effective against COVID-19 in vitro and in vivo. DTBN inhibits SARS-CoV-2 production, reduces viral load in lungs, and exhibits anti-inflammatory properties, making it a promising candidate against the virus. Further studies are needed to optimize its use.

COVID-19 Nuphar lutea
Weiss S et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24098327
PubMed:
37176034

Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L.

Pomegranate's polyphenols may inhibit SARS-CoV-2 and regulate immune responses. It has potential as a COVID-19 treatment and may help replenish antioxidants during recovery.

COVID-19 Punica granatum
Alexova R et al (2023).
Molecules.
DOI:
10.3390/molecules28093772
PubMed:
37175181

Identifying potent inhibitory phytocompounds from Lagerstroemia speciosa against SARS-Coronavirus-2: structure-based virtual screening.

Researchers found that 24-methylene cycloartanol acetate may inhibit envelope viroporin protein and RNA-directed RNA polymerase, while sitosterol acetate may target SARS-CoV-2 main protease, spike glycoprotein, and human receptor ACE2. Further testing is needed to confirm their safety and effectiveness as potential therapeutics. (63 words)

COVID-19 Lagerstroemia speciosa
Singh Dagur H et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2205942
PubMed:
37170794

Investigation of the antiviral effects of Saussurea lappa root extract against SARS-CoV-2 virus.

Researchers found that a plant extract from Saussurea lappa roots could potentially be used as a food supplement to combat SARS-CoV-2, as it showed some ability to inhibit the virus. Further research is needed to establish its effectiveness as a treatment for COVID-19.

AntimicrobialCOVID-19 Saussurea lappa
Polat HU et al (2023).
Mol Nutr Food Res.
DOI:
10.1002/mnfr.202200804
PubMed:
37170075

In silico study of potential SARS-CoV-2 antagonist from Clitoria ternatea.

Researchers used a computer-based approach to identify natural compounds that may inhibit a viral protein, offering a potential avenue for developing new antiviral drugs. (33 characters)

COVID-19 Clitoria ternatea
Chun CY et al (2023).
Int J Health Sci (Qassim).
PubMed:
37151745

Bioprospecting phytochemicals of Rosmarinus officinalis L. for targeting SARS-CoV-2 main protease (M(pro)): a computational study.

Researchers seek alternative therapies for COVID-19, exploring the potential of targeting the main protease (M) to control viral replication and prevent infections, amid concerns over vaccine effectiveness.

COVID-19 Rosmarinus officinalis
Patel U et al (2023).
J Mol Model.
DOI:
10.1007/s00894-023-05569-6
PubMed:
37115321

Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery.

This article examines the potential of Wedelia chinensis (WS) as a treatment for COVID-19. WS has shown antiviral effects against SARS-CoV and SARS-CoV-2. It summarizes studies on WS extracts and compounds, and suggests that WS could be a long-term solution to prevent drug resistance.

COVID-19 Withania somnifera
Ramli S et al (2023).
Microorganisms.
DOI:
10.3390/microorganisms11041000
PubMed:
37110423

The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis.

Dehydroandrographolide (Deh) is a compound found in Andrographis paniculata that has been shown to have potent anti-inflammatory and antioxidant properties. Its potential use in medicine warrants further exploration.

COVID-19 Andrographis paniculata
Pu Z et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154753
PubMed:
37084628
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