Covid-19 Studies

Anti-COVID-19 Potential of Withaferin-A and Caffeic Acid Phenethyl Ester.

Researchers have been studying the development of vaccines, repurposing approved drugs, and natural compounds for COVID-19. Gender differences in disease severity suggest that sex hormones could be involved. Androgens upregulate ACE2, a key receptor for the virus, while androgen antagonists can lower ACE2 levels, potentially aiding in COVID-19 management.

COVID-19 Withania somnifera
Kumar V et al (2024).
Curr Top Med Chem.
DOI:
10.2174/0115680266280720231221100004
PubMed:
38279743

Antihypertensive and ACE-2 Inhibitory Effects of Daphne gnidium in Rats.

Daphne gnidium plant was investigated for its ability to lower blood pressure. Relevant for finding potential natural remedies to combat hypertension.

COVID-19 Daphne gnidium
Bouadid I, Qabouche A and Eddouks M (2024).
Cardiovasc Hematol Agents Med Chem.
DOI:
10.2174/0118715257251651231212045407
PubMed:
38279710

Identification of antiviral phytochemicals from cranberry as potential inhibitors of SARS-CoV-2 main protease (M(pro)).

Researchers identified cranberry phytochemicals with antiviral activity against SARS-CoV-2 main protease. Lead compounds were cyanidin 3-O-galactoside, β-carotene, and epicatechin. Cyanidin showed the highest inhibitory potential. Cranberry extracts containing anthocyanins also exhibit potential. Used for therapeutic interventions against SARS-CoV-2.

AntimicrobialCOVID-19 Vaccinium macrocarpon
Pillai U J et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129655
PubMed:
38266830

In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19.

Immunosenescence and age-related immune system changes contribute to the severity of COVID-19. Glycyrrhiza glabra in a polyherbal formulation boosts immunity and has antiviral properties. Phytoconstituents, particularly liquiritigenin, inhibit the major protease protein of SARS-CoV-2, highlighting potential for clinical drug development.

COVID-19Phytochemistry Glycyrrhiza glabra
Sekaran K et al (2024).
Adv Protein Chem Struct Biol.
DOI:
10.1016/bs.apcsb.2023.04.003
PubMed:
38220426

An investigation into the usage of black cumin derivatives against cancer and COVID-19 as the nature medicine.

The study analyzed black cumin compounds using theoretical calculations to determine their effectiveness in inhibiting HDAC2. The active substances were found to protect ACE2 against COVID-19, making them potentially valuable for lab decisions. [25 words]

COVID-19Cancer Nigella sativa
Gökalp F et al (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2024.2302942
PubMed:
38197611

In-silico evaluation of natural alkaloids against the main protease and spike glycoprotein as potential therapeutic agents for SARS-CoV-2.

Scientists studied 102 alkaloids and found six from the lotus plant that can potentially treat COVID-19 by targeting the spike protein and protease of SARS-CoV-2, aiding drug discovery with minimal side effects.

COVID-19Phytochemistry Nelumbo nucifera
Shah M et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0294769
PubMed:
38175855

Plant extracts modulate cellular stress to inhibit replication of mouse Coronavirus MHV-A59.

Plant extracts P2Et and Anamu SC were tested for their ability to inhibit murine hepatitis virus replication. P2Et reduced virus replication and cellular stress, while Anamu SC inhibited infection but induced some negative effects. These findings suggest the potential of plant extracts as antiviral therapies.

COVID-19 Petiveria alliacea
Prieto K et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e23403
PubMed:
38169850

Isolation and in silico investigation of cannflavins from Cannabis sativa leaves as potential anti-SARS-CoV-2 agents targeting the Papain-Like Protease.

This study identified three prenylflavonoids from leaves that show potential against SARS-CoV-2. The compounds have structural similarities to a ligand of the virus' Papain-Like Protease and successfully bind to its active pocket. Further research is needed to confirm their effectiveness and safety.

COVID-19 Cannabis sativa
Wanas AS et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2294111
PubMed:
38100380
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