Covid-19 Studies

Formulation and in vitro characterization of nanoemulsions containing remdesivir or licorice extract: A potential subcutaneous injection for coronavirus treatment.

Researchers formulated and characterized remdesivir and licorice extract nanoemulsions for subcutaneous injection against coronavirus. Licorice extract nanoemulsion showed better release and stability, making it a potential treatment for mild to moderate coronavirus.

COVID-19 Glycyrrhiza glabra
Al Ashmawy AZG and Balata GF (2024).
Colloids Surf B Biointerfaces.
DOI:
10.1016/j.colsurfb.2023.113703
PubMed:
38096607

Repurposing of Rutan showed effective treatment for COVID-19 disease.

Researchers repurposed the Rutan drug from the tannic sumac plant and found that it effectively and safely treats COVID-19 by inhibiting key enzymes of the virus. Clinical studies showed reduced inflammation and shorter viremia period. Rutan can be a safe treatment and preventive measure for adults and children.

COVID-19 Rhus coriaria
Salikhov SI et al (2023).
Front Med (Lausanne).
DOI:
10.3389/fmed.2023.1310129
PubMed:
38093975

Danshensu inhibits SARS-CoV-2 by targeting its main protease as a specific covalent inhibitor and discovery of bifunctional compounds eliciting antiviral and anti-inflammatory activity.

Salvia miltiorrhiza and its active ingredient Danshensu have shown to inhibit SARS-CoV-2 and possess anti-inflammatory properties. Danshensu is a covalent inhibitor of the 3CL protease of SARS-CoV-2, making it a potential candidate for targeted drug development against COVID-19.

AntimicrobialCOVID-19Immunology Salvia
Wang R et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128623
PubMed:
38070810

Discovery of Anti-Coronavirus Cinnamoyl Triterpenoids Isolated from Hippophae rhamnoides during a Screening of Halophytes from the North Sea and Channel Coasts in Northern France.

Scientists investigated plants adapted to high-salt environments in France for potential antiviral properties against SARS-CoV-2. The plant showed the highest antiviral activity, and six cinnamoyl triterpenoid compounds were identified as potential antiviral agents against coronaviruses.

COVID-19 Hippophae rhamnoides
Al Ibrahim M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242316617
PubMed:
38068938

Inhibition of SARS-CoV-2 infection and replication by Petasites hybridus CO2-extract (Ze 339).

This study investigated the antiviral effects of a CO-extract from Petasites hybridus (Ze 339). The search for herbal anti-viral drugs is important in preventing early stages of infection, especially in the context of the SARS-CoV-2 Omicron variant and the lack of available drugs for alleviating symptoms and preventing Long-COVID.

COVID-19 Petasites hybridus
Jakwerth CA et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115959
PubMed:
38061134

Adhatoda vasica and Tinospora cordifolia extracts ameliorate clinical and molecular markers in mild COVID-19 patients: a randomized open-label three-armed study.

Scientists studied the effects of SARS-CoV-2 infections and found that while most cases are mild, a significant number of infected individuals develop severe respiratory illness. This highlights the need for a safe and effective treatment for COVID-19.

COVID-19 Tinospora cordifolia
Verma M et al (2023).
Eur J Med Res.
DOI:
10.1186/s40001-023-01507-7
PubMed:
38049897

Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial.

This study found that inhaling marjoram essential oil at work can potentially reduce stress and anxiety levels of nurses in a COVID-19 ICU. This may lead to better quality of patient care.

COVID-19NeurosciencePhytochemistry Origanum majorana
Lee SW et al (2023).
Front Psychiatry.
DOI:
10.3389/fpsyt.2023.1287282
PubMed:
38045619

Chemical Composition of Thyme (Thymus vulgaris) Extracts, Potential Inhibition of SARS-CoV-2 Spike Protein-ACE2 Binding and ACE2 Activity, and Radical Scavenging Capacity.

Thyme extracts inhibited SARS-CoV-2 spike protein-ACE2 interaction and ACE2 activity. They also showed strong antioxidant properties. Thyme extract could potentially prevent and reduce complications from SARS-CoV-2 infection.

COVID-19 Thymus vulgaris
Yao Y et al (2023).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c05432
PubMed:
38039415
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