Covid-19 Studies

COVID-19 patient with B cell lymphoma co-morbidity managed with co-administration of ayurvedic formulation.

A 47-year-old male with chronic kidney disease and B Cell Lymphoma successfully recovered from COVID-19 using a poly-herbal ayurvedic formulation and integrated approach while in home quarantine. The patient had recently finished chemotherapy, making treatment challenging; however, he tolerated the intervention and recovered symptomatically without respiratory complications. Ayurvedic herbs have demonstrated anti-viral and immunomodulatory effects in in vitro studies, and this case supports their potential efficacy in real-world patients when combined with Ayurvedic epistemology. Early diagnosis by RT-PCR and early use of Ayurvedic interventions may be essential for successful recovery.

COVID-19Cancer Achyranthes aspera
Dilip Pandkar P, Deshmukh SR and Sachdeva V (2022).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2022.100632
PubMed:
35975131

Phenolic compounds of Zanthoxylum armatum DC as potential inhibitors of urease and SARS-CoV2 using molecular docking approach and with simulation study.

Researchers evaluated the anti-urease effects of compounds found in the leaves of Datura ceratocaula. Three phenolic compounds were identified and found to interact significantly with both urease and SARS-CoV2 vital proteins. Chlorogenic acid was the most effective in interacting with both urease and the coronavirus main protease, while gallic acid was effective in interacting with five spike proteins of SARS-CoV2. The compounds also passed several tests for drug-likeness and could potentially be used as antagonists of urease.

COVID-19Phytochemistry Zanthoxylum armatum
Chelleng N et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2110096
PubMed:
35968637

Broad-spectrum antiviral activity of Spatholobus suberectus Dunn against SARS-CoV-2, SARS-CoV-1, H5N1, and other enveloped viruses.

Scientists have found that an extract of Spatholobus suberectus Dunn (SSP), a medicinal plant, has broad-spectrum antiviral properties against SARS-CoV-1 and 2, HIV-1, and H5N1. SSP effectively inhibits viral entry, with EC values ranging from 3.6 to 5.1 μg/ml. Pre-treatment of pseudovirus or target cells with SSP showed consistent inhibitory activities with the respective EC value of 2.3 or 2.1 μg/ml. SSP blocked both SARS-CoV-2 spike glycoprotein and the host ACE2 receptor without toxic behavior. This plant extract has promising potential to be developed as a drug candidate for preventing and treating COVID-19 and other emerging enveloped viruses.

AntimicrobialCOVID-19 Spatholobus suberectus
Liu Q et al (2022).
Phytother Res.
DOI:
10.1002/ptr.7452
PubMed:
35943221

Molecular dynamics and docking studies on potentially active natural phytochemicals for targeting SARS-CoV-2 main protease.

Researchers discovered that three compounds, Aegelinosides B, Epicatechin, and Feruloyltyramine, from popular herbs are potential candidates for fighting SARS-CoV-2. These compounds were screened from 87 phytochemicals and identified based on their binding energy and structural stability through molecular dynamics analysis. Comparing to popular reference compounds, Aegelinosides B demonstrated the best result. Further drug-likeness and toxicity tests also support the effectiveness of these compounds. These findings may have implications for developing treatments against COVID-19.

COVID-19 Aegle marmelosAerva lanataBiophytum sensitivumColeus amboinicus
Karakkadparambil Sankaran S and Nair AS (2022).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2107573
PubMed:
35930306

Hesperidin hexosomal loaded nanodispersion: insights of its antimycobacterial, cytotoxic and anti-HCoV effects.

Valencia oranges contain hesperidin which has anti-TB and antiviral activity. Hesperidin was isolated and formulated as nanodispersions which showed a MIC of 0.19 µM against TB and significant interactions with the Mycobacterial Dihydrofolate reductase enzyme. The nanodispersions also had a cytotoxic effect against lung cancer at IC=33 µM and significant antiviral activity against Human Coronavirus 229E with IC=258.8 μM. This study suggests that Valencia orange peels could be a source of bioactive metabolites for treating diseases.

COVID-19 Citrus sinensis
Elghani EMA et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2106484
PubMed:
35921497

Protective and therapeutic potentials of HDL and ApoA1 in COVID-19 elderly and chronic illness patients.

Scientists have discovered that HDL, a protein responsible for various functions in the body, is affected by alterations in its structure caused by SARS-CoV-2. This discovery sheds light on the increased risk of severe COVID-19 in older adults, obese individuals, and those with chronic illnesses. The study's findings could potentially lead to new treatments that target HDL to improve outcomes for these vulnerable populations.

COVID-19 Saussurea lappa
AbdelHafez MA et al (2022).
Bull Natl Res Cent.
DOI:
10.1186/s42269-022-00886-x
PubMed:
35915785

Removal of clinically relevant SARS-CoV-2 variants by an affinity resin containing Galanthus nivalis agglutinin.

Researchers investigated the effectiveness of plant lectin Galanthus nivalis for binding to the SARS-CoV-2 virus and its variants to develop therapies for severe COVID-19 cases. They tested seven clinically relevant variants and found that viral capture efficiency ranged from 53% to 89%. The study indicated that the use of Galanthus nivalis can be effective and practical in treating severe COVID-19 patients.

COVID-19 Galanthus nivalis
Gooldy M et al (2022).
PLoS One.
DOI:
10.1371/journal.pone.0272377
PubMed:
35901224

Antiviral activity of medicinal plant-derived products against SARS-CoV-2.

Extracts and phytocompounds from medicinal plants have been shown to have antiviral activity against SARS-CoV-2. These plant products impede the virus from attaching to host cells and prevent its multiplication inside the cell. They also have an immunomodulatory effect by controlling the release of cytokines associated with SARS-CoV-2 infections. These findings demonstrate the potential of plant-based treatments for COVID-19.

AntimicrobialCOVID-19 Artemisia afra
de Oliveira JR et al (2022).
Exp Biol Med (Maywood).
DOI:
10.1177/15353702221108915
PubMed:
35894129
1 16 25 26 27 36 38