Covid-19 Studies

The efficacy of herbal medicines on the length of stay and negative conversion time/rate outcomes in patients with COVID-19: a systematic review.

Researchers conducted a systematic review on herbal medicines as adjuvant therapy for COVID-19, analyzing clinical trials from various countries. Results focused on Length of Stay, Negative Conversion Time, and Negative Conversion Rate. Important for potential alternative treatment options.

Latarissa IR et al (2024).
Front Pharmacol.
PubMed:
38873430

Structural and Functional Characterization of Medicinal Plants as Selective Antibodies towards Therapy of COVID-19 Symptoms.

Researchers investigated medicinal plants as potential therapies for COVID-19, using quantum sensing methods to analyze their interactions with COVID protein. Results suggest these plants could be effective against COVID-19 symptoms, aiding drug design efforts.

Mollaamin F et al (2024).
Antibodies (Basel).
PubMed:
38804306

Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations.

Endophytic fungus from fruit peels produces compounds with potential antibacterial and antiviral properties. Strong activity against MRSA and biofilm formation, weak against Gram-negative bacteria. Promising antiviral activity against HCoV 229E. Molecular docking shows potential as drug targets.

Fathallah N et al (2024).
Pharmaceuticals (Basel).
PubMed:
38794226

Safety and Efficacy of the Ayurvedic Formulation Guduchi Ghana Vati as a Preventive Remedy in COVID-19.

Guduchi Ghana Vati showed potential as a preventive remedy for COVID-19 and other infections in a healthy population, with lower severity and hospitalization requirements in those taking it. It is safe and effective for preventing infections and boosting immunity.

Sharma S et al (2024).
Cureus.
PubMed:
38784353

Isolation, Virtual Screening, and Evaluation of Hazelnut-Derived Immunoactive Peptides for the Inhibition of SARS-CoV-2 Main Protease.

Hazelnut peptides WWNLN and WAVLK inhibit SARS-CoV-2 protease M, boosting immune cell function and cytokine release. WWNLN shows stronger inhibition and better pharmacokinetic properties. Important for developing antiviral treatments.

Liu X et al (2024).
J Agric Food Chem.
PubMed:
38739709

Two Novel Angiotensin-Converting Enzyme (ACE) Inhibitory and ACE2 Upregulating Peptides from the Hydrolysate of Pumpkin (Cucurbita moschata) Seed Meal.

Researchers used pumpkin seed meal to create ACE inhibitory and ACE2 upregulating peptides. Two identified peptides showed significant ACE inhibition activity and were stable during digestion. These peptides have potential as antihypertensive agents.

Li X et al (2024).
J Agric Food Chem.
PubMed:
38689562

Nanostructured lipid carriers loaded with essential oils: a strategy against SARS-CoV-2.

NLCs loaded with essential oils inhibit SARS-CoV-2, with promising results exceeding 2-log reduction in virion count. Innovative strategy for combating SARS-CoV-2.

Almeida LF et al (2024).
J Microencapsul.
PubMed:
38686964

Serum Clusterin Concentration and Its Glycosylation Changes as Potential New Diagnostic Markers of SARS-CoV-2 Infection and Recovery Process.

Study found lower CLU concentrations, higher levels of specific glycan reactivities in severe COVID-19 patients compared to convalescents and healthy individuals. These glycomarkers could help differentiate disease severity.

Sołkiewicz K et al (2024).
Int J Mol Sci.
PubMed:
38673784