Covid-19 Studies

Nigella sativa, Anthemis hyaline and Citrus sinensis extracts reduce SARS-CoV-2 replication by fluctuating Rho GTPase, PI3K-AKT, and MAPK/ERK pathways in HeLa-CEACAM1a cells.

Anthemis hyaline, Nigella sativa, and Citrus sinensis extracts show promise in inhibiting coronavirus replication. Nigella sativa increases IL-8 levels and gene expression changes. Anthemis hyaline extract is the most effective in reducing viral load.

COVID-19Immunology Citrus sinensisNigella sativa
Bostancıklıoğlu M, İğci M and Ulaşlı M (2024).
Gene.
DOI:
10.1016/j.gene.2024.148366
PubMed:
38485035

SAR, Molecular Docking and Molecular Dynamic Simulation of Natural Inhibitors against SARS-CoV-2 Mpro Spike Protein.

Plant compound kaempferol was found to have strong binding affinity with SARS-CoV-2 main protease, suggesting potential for new COVID-19 treatment. This research could lead to the development of effective antiviral drugs.

COVID-19 Carica papayaPyrus communis
Salamat A et al (2024).
Molecules.
DOI:
10.3390/molecules29051144
PubMed:
38474656

Inhibitory Efficacy of Main Components of Scutellaria baicalensis on the Interaction between Spike Protein of SARS-CoV-2 and Human Angiotensin-Converting Enzyme II.

This study explores using Traditional Chinese Medicine to target the interaction between SARS-CoV-2 variants and human cells, finding baicalein and baicalin from () to be effective inhibitors. Further research on these compounds is warranted for potential COVID-19 treatment.

COVID-19 Scutellaria baicalensis
Lin CH et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25052935
PubMed:
38474182

Characterization of chitosan/Persian gum nanoparticles for encapsulation of Nigella sativa extract as an antiviral agent against avian coronavirus.

Researchers studied nanoparticles made from chitosan and WPG for delivering NSE as an antiviral agent. At 1:1 MR and 6.25 mg/mL NSE, nanoparticles showed promising antiviral activity against IBV, suggesting potential use in poultry and human medicine.

AntimicrobialCOVID-19 Nigella sativa
Hadian M et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130749
PubMed:
38467218

Effects of Lamiaceae family plants and their bioactive ingredients on coronavirus-induced lung inflammation.

Two plants in the Lamiaceae family show promise in treating CoV-induced inflammation. Thymol and carvacrol have antiviral and anti-inflammatory properties, reducing inflammatory mediators and enhancing antioxidant capacity. Potential treatment for CoV-induced lung disorder.

COVID-19Immunology Thymus vulgaris
Kianmehr M et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3903
PubMed:
38455203

Ayush [Indian System of Medicines] Prophylaxis Against COVID-19: A Living Systematic Review and Meta-Analysis (Second Update).

Ayush medicine shows potential for preventing COVID-19 infections. More high-quality studies are needed to confirm efficacy and safety. Policymakers should consider this evidence for decision-making.

COVID-19 Tinospora cordifolia
Thakar A et al (2024).
J Integr Complement Med.
DOI:
10.1089/jicm.2023.0357
PubMed:
38422192

Long COVID-19 gastrointestinal related disorders and traditional Chinese medicine: A network target-based approach.

Research reviewed nutraceuticals from Traditional Chinese Medicine for relieving Long COVID-19 gastrointestinal symptoms. Identified plants such as Cinnamomum cassia and Salvia miltiorrhiza show promise in reducing inflammation and oxidative stress. These natural remedies may offer multi-target therapeutic benefits for Long COVID-19 complications.

COVID-19 Cinnamomum cassiaGlycyrrhiza uralensisMagnolia officinalisScutellaria baicalensis
Mattioli LB et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8163
PubMed:
38421118

Steroidal lactones from Withania somnifera effectively target Beta, Gamma, Delta and Omicron variants of SARS-CoV-2 and reveal a decreased susceptibility to viral infection and perpetuation: a polypharmacology approach.

Withania somnifera (WS) has potent immunomodulatory, anticancer, and antiviral properties against COVID-19, especially in cancer patients. Withanolides in WS extract show promising cytotoxicity against SARS-CoV-2 and pro-inflammatory markers. Further research is needed for potential therapy.

COVID-19 Withania somnifera
Srivastava A et al (2024).
In Silico Pharmacol.
DOI:
10.1007/s40203-023-00184-y
PubMed:
38419919
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