Antioxidant, antihypertensive, anti-hyperglycemic, and antimicrobial activity of aqueous extracts from twelve native plants of the Yucatan coast.

Rodríguez-García CM et al (2019).

PLoS One.

DOI:

10.1371/journal.pone.0213493

PubMed:

30917135

In vitro evaluation of the α-glucosidase inhibitory potential of methanolic extracts of traditionally used antidiabetic plants.

Bhatia A et al (2019).

BMC Complement Altern Med.

DOI:

10.1186/s12906-019-2482-z

PubMed:

30909900

Antioxidant and alpha amylase inhibitory activities of Fumaria officinalis and its antidiabetic potential against alloxan induced diabetes.

Fatima S et al (2019).

Cell Mol Biol (Noisy-le-grand).

PubMed:

30860471

Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety.

Jia Q et al (2019).

Phytomedicine.

DOI:

10.1016/j.phymed.2019.152871

PubMed:

30851580

Dianthus superbus Improves Glomerular Fibrosis and Renal Dysfunction in Diabetic Nephropathy Model.

Yoon JJ et al (2019).

Nutrients.

DOI:

10.3390/nu11030553

PubMed:

30841605

Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats.

Balakrishnan BB et al (2019).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2019.108688

PubMed:

30798121

Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and inflammation in high fat diet/streptozotocin treated rats.

Ni Z et al (2019).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2019.108678

PubMed:

30784905

Korean Thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.): A Potential Dietary Supplement against Diabetes and Alzheimer's Disease.

Researchers investigated the activity of different parts of Korean thistle for their potential to inhibit diabetes and Alzheimer's disease. Ethyl acetate and dichloromethane fractions of the leaf extract showed α-glucosidase and BACE1 inhibitory activity, respectively. Luteolin, an isolated compound, also exhibited non-competitive inhibition against both α-glucosidase and BACE1. Docking studies showed that luteolin formed a strong hydrogen bond with the peripheral binding amino acid residues and hydrophobic interactions with the enzymes. Korean thistle may be a dietary supplement against these diseases, especially the leaves, due to the preponderance of active luteolin. This promising candidate warrants further in vitro and in vivo studies.

Wagle A et al (2019).

Molecules.

DOI:

10.3390/molecules24030649

PubMed:

30759846