Dianthrone derivatives from Polygonum multiflorum Thunb: Anti-diabetic activity, structure-activity relationships (SARs), and mode of action.
- Yang JB et al (2023).
- Bioorg Chem.
- PubMed:
- 37011521
Researchers evaluated the effects of Eryngium carlinae, a plant used in Mexican traditional medicine to treat diabetes, on brain function in diabetic rats. They used green synthesis to make nanoparticles that enhance the plant's properties. Results showed that both the plant extract and its nanoparticle combination reduced the production of reactive oxygen species, lipid peroxidation and restored mitochondrial function in the brain. The extract-nanoparticle combination also decreased blood glucose and triglyceride levels. These findings suggest that both treatments could be beneficial for treating diabetes.