Exploring the Mechanism of Brucea Javanica against Ovarian Cancer based on Network Pharmacology and the Influence of Luteolin on the PI3K/AKT Pathway.

Researchers studied the Chinese herbal medicine Brucea javanica for ovarian cancer treatment. Its effectiveness and mechanism were unknown, but if proven effective, it could offer new treatment options for this frequently diagnosed cancer.

Zhu J et al (2023).

Comb Chem High Throughput Screen.

DOI:

10.2174/1386207326666230627114111

PubMed:

37366364

Can flaxseed, chia or puncture vine affect mare ovarian cell functions and prevent the toxic effect of the environmental contaminant toluene?

This study shows that flaxseed, chia, and puncture vine can affect mare ovarian cell functions and their response to the contaminant toluene. Flaxseed and puncture vine can mitigate toluene's harmful effects.

Sirotkin AV et al (2023).

Theriogenology.

DOI:

10.1016/j.theriogenology.2023.06.018

PubMed:

37354861

Hepatoprotective effect of Artemisia Argyi essential oil on bisphenol A-induced hepatotoxicity via inhibition of ferroptosis in mice.

Artemisia argyi essential oil (AAEO) protects the liver from the toxic effects of BPA by reducing liver enzyme levels, improving liver health, and preventing ferroptosis.

Cui W et al (2023).

Environ Toxicol.

DOI:

10.1002/tox.23877

PubMed:

37347548

Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes.

Chen MY et al (2023).

Am J Chin Med.

DOI:

10.1142/S0192415X23500556

PubMed:

37335210

Computational investigation of four isoquinoline alkaloids against polycystic ovarian syndrome.

Moka MK, S AS and M S (2024).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2222828

PubMed:

37315995

The Phytoestrogenic Effect of Hibiscus sabdariffa Involves Estrogen Receptor α in Ovariectomized Wistar Rats.

The researchers found that an extract from the calyxes of Hibiscus sabdariffa improves memory and may act as a phytoestrogen, providing a potential alternative to hormone replacement therapy.

Lorenzana-Martínez G et al (2023).

Plant Foods Hum Nutr.

DOI:

10.1007/s11130-023-01061-x

PubMed:

37314593

Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model.

A complex extract of PS and NS improves menopause symptoms in rats without side effects like endometriosis. It increases estrogen receptors and improves blood-lipid metabolism and osteoporosis.

Park D et al (2023).

Nutrients.

DOI:

10.3390/nu15112443

PubMed:

37299404

Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways.

Neferine, an alkaloid, reduces prostate cell proliferation in mice with BPH. It inhibits growth and ROS production in human prostate cells, suggesting it as a potential treatment for BPH.

Liu CM et al (2023).

Saudi Pharm J.

DOI:

10.1016/j.jsps.2023.05.004

PubMed:

37293563