Endocrinology Studies

Transcriptome, Plant Hormone, and Metabolome Analysis Reveals the Mechanism of Purple Pericarp Formation in 'Zihui' Papaya (Carica papaya L.).

'Zihui' papaya has purple pericarp due to upregulation of genes involved in anthocyanin synthesis. Understanding this mechanism can enhance fruit marketability and improve visual appeal.

Wu X et al (2024).
Molecules.
PubMed:
38611765

Antineoplastic Drug Synergy of Artesunate with Navitoclax in Models of High-Grade Serous Ovarian Cancer.

Researchers found artesunate, a drug for severe malaria, enhances cell death in ovarian cancer when combined with navitoclax. This combo shows promising antineoplastic effects in both cell and animal models, hinting at a potential new treatment option for ovarian cancer.

McCorkle JR et al (2024).
Cancers (Basel).
PubMed:
38610999

Ganoderma lucidum and Hypericum perforatum exhibit anti-inflammatory, antioxidant and anti-androgen effect in rat model of experimental polycystic ovarian syndrome.

Tossers investigated GLP and HP for their anti-inflammatory and antioxidant effects on ovarian tissue in rats with PCOS. Results could help understand and potentially treat inflammation-related aspects of PCOS.

Okay G et al (2024).
Med Princ Pract.
PubMed:
38599178

Phytochemical identification and in silico elucidation of interactions of bioactive compounds from Citrullus lanatus with androgen receptor towards prostate cancer treatment.

Study investigated fruit compounds as potential AR inhibitors for prostate cancer therapy. Naringenin showed promising results in binding to AR. Further research on these compounds, especially naringenin, may lead to new drug development.

Demian MD et al (2024).
In Silico Pharmacol.
PubMed:
38596366

Mitigation of letrozole induced polycystic ovarian syndrome associated inflammatory response and endocrinal dysfunction by Vitex negundo seeds.

Researchers studied the use of Vitex negundo seed in treating polycystic ovary syndrome in rats. Results may offer safer and more effective treatment options for PCOS in women.

Kar TK et al (2024).
J Ovarian Res.
PubMed:
38589892

Detection of isoflavones and phytoestrogen-rich plant extracts binding to estrogen receptor β using a yeast-based fluorescent assay.

Scientists evaluated the binding affinities of phytoestrogens from medicinal plants for estrogen receptor β, using a yeast-based fluorescent assay. This can help identify potential treatments for gynecological diseases and assess environmental substances affecting the female reproductive system.

Bekić S et al (2024).
Anal Biochem.
PubMed:
38582243

Nano zinc oxide mediated resuscitation of aged Cajanus cajan via modulating aquaporin, cell cycle regulatory genes and hormonal responses.

Nanoparticles rejuvenate aging Cajanus cajan seeds, improving germination and viability by regulating redox status, gene expression, and hormonal balance. This research shows potential for nanotechnology in agriculture and the importance of using nano zinc oxide for seed treatment.

Kaur R et al (2024).
Plant Cell Rep.
PubMed:
38564104

Acyl-CoA-binding protein (ACBP) genes involvement in response to abiotic stress and exogenous hormone application in barley (Hordeum vulgare L.).

Researchers studied the role of ACBPs in barley, uncovering their importance in growth, stress response, and membrane repair. Understanding this can aid in developing resilient crops.

Chang H et al (2024).
BMC Plant Biol.
PubMed:
38561660