Endocrinology Studies

Luteolin and its analog luteolin-7-methylether from Leonurus japonicus Houtt suppress aromatase-mediated estrogen biosynthesis to alleviate polycystic ovary syndrome by the inhibition of tumor progression locus 2.

Researchers studied the traditional use of L. japonicus in treating estrogen-related gynecological disorders. Understanding its mechanism could lead to new treatments for conditions like PCOS.

Shi XK et al (2024).
J Ethnopharmacol.
PubMed:
38705425

Angelica sinensis polysaccharide combined with cisplatin reverses cisplatin resistance of ovarian cancer by inducing ferroptosis via regulating GPX4.

Angelica sinensis polysaccharide (ASP) reverses cisplatin resistance in ovarian cancer cells by suppressing GPX4 expression. ASP in combination with cisplatin shows promise in overcoming drug resistance.

Guo W et al (2024).
Biomed Pharmacother.
PubMed:
38703506

The Potential Role of Phytochemicals of Juniperus procera in the Treatment of Ovarian Cancer and the Inhibition of Human Topoisomerase II Alpha Activity.

Fruit and leaf extracts from medicinal plants show promise as potential anticancer drugs, inhibiting ovarian cancer cells and targeting key enzymes, offering new avenues for drug development.

Al-Zahrani AA et al (2024).
Bioinform Biol Insights.
PubMed:
38681095

Ameliorative effects of elderberry (Sambucus nigra L.) extract and extract-derived monosaccharide-amino acid on H2O2-induced decrease in testosterone-deficiency syndrome in a TM3 Leydig cell.

Elderberry extract and FL improve testosterone production and reduce oxidative stress in Leydig cells. Potential natural alternative to testosterone-replacement therapy for age-related testosterone-deficiency syndrome.

Lee S et al (2024).
PLoS One.
PubMed:
38662754

Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats.

Ethanol extract from seeds inhibits estrogen-dependent conditions in rats by interacting with estrogen receptors. Can act as partial agonist or antagonist of estradiol. Relevant for studying phytoestrogens as potential treatments.

Minko Essono S et al (2024).
J Complement Integr Med.
PubMed:
38661065

Urtica pilulifera L. seed extract promotes folliculogenesis and alleviates the diminished ovarian reserve in the Balb/c mice model: An experimental study.

Seed (UPS) is a traditional Persian medicine for female infertility. Research shows positive effects. Consider for treatments in your lab.

Hekmat S et al (2024).
Int J Reprod Biomed.
PubMed:
38628780

Withania somnifera and Trigonella foenum-graecum as ingredients of testosterone-boosting supplements: Possible clinical implications.

Review of dietary supplements affecting testosterone levels. Two extracts, Withania somnifera and Trigonella foenum-graecum, shown to increase T levels in men through different mechanisms. Important for selecting effective supplements for lab use.

Skrzypiec-Spring M et al (2024).
Adv Clin Exp Med.
PubMed:
38628109

The impact of chemical and hormonal treatments to improve seed germination and seedling growth of Juniperus procera Hochst. ex Endi.

Study looked at ways to improve seed germination and seedling growth in Saudi Arabian juniper trees to combat declining populations. Important for restoring natural forests.

Jabbour AA and Alzahrani A (2024).
PeerJ.
PubMed:
38618572