Gastroenterology Studies

Cytotoxic and molecular evaluation of spilanthol obtained from Acmella oleracea (L.) R. K. Jansen (jambu) in human gastric cancer cells.

A study investigated the anticancer activity of jambu, a plant found in the Brazilian Amazon. The hydroethanolic extract of jambu was obtained, and its active compound, spilanthol, was isolated. The extract and spilanthol both exhibited cytotoxicity against gastric cancer cells. Furthermore, molecular docking experiments revealed that spilanthol has inhibitory potential against JAK1 and JAK2 proteins. These findings suggest that jambu extract and spilanthol could be potential candidates for the treatment of gastric carcinoma.

Pinheiro MSDS et al (2023).
Nat Prod Res.
PubMed:
37300460

Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2/PGE2 cascade.

Salvia miltiorrhiza Bunge, a Chinese medicinal herb known for invigorating blood circulation, has shown promising results in treating cancer. Inspired by traditional Chinese medicine, this study highlights the potential of Salvia miltiorrhiza as an effective treatment option. Its significant role in combating cancer makes it a valuable addition to the field of medicine.

Song M et al (2023).
J Ethnopharmacol.
PubMed:
37286115

Low glycemic index potato biscuits alleviate physio-histological damage and gut dysbiosis in rats with type-2 diabetes mellitus induced by high-sugar and high-fat diet and streptozotocin.

This study found that low-glycemic index (GI) potato biscuits with oat bran and inulin improved type 2 diabetes in rats by reducing blood glucose levels and reversing metabolic disorders. These biscuits also positively affected the gut microbiota.

Zhao R et al (2023).
J Nutr Biochem.
PubMed:
37276891