Immunology Studies

Phenolic composition, antioxidant, and cytotoxic effects on HeLa and HepG2 cancer cell lines of Mespilus germanica grown in Turkey.

In this study, researchers examined the antioxidant and cytotoxic properties of flavonoids and phenolic acids found in Turkish medlar. Using advanced analysis techniques, they identified various compounds in leaf and fruit extracts. Notably, the fruit extract showed excellent antioxidant properties, while the leaf extract demonstrated strong cytotoxicity against cancer cells. These findings suggest that Turkish medlar could be a valuable natural source for developing anticancer and antioxidant agents in the food and pharmaceutical industries.

Yunusa UM and Ozturk Urek R (2023).
Nat Prod Res.
PubMed:
37395516

A Standardized Extract of Petasites hybridus L., Containing the Active Ingredients Petasins, Acts as a Pro-Oxidant and Triggers Apoptosis through Elevating of NF-κB in a Highly Invasive Human Breast Cancer Cell Line.

A Bulgarian butterbur root extract, rich in petasins, was tested for its anti-cancer properties on breast cancer cells and non-cancerous cells. The study investigated cell death, oxidative stress, and NF-κB signaling. This research is important as it highlights the anti-tumor potential of a traditional medicinal plant, providing insights into possible future treatments for breast cancer.

Apostolova S et al (2023).
Front Biosci (Landmark Ed).
PubMed:
37395030

Deacetyl epoxyazadiradione ameliorates BPA-induced neurotoxicity by mitigating ROS and inflammatory markers in N9 cells and zebrafish larvae.

A study investigates the potential protective effects of a neem-derived compound, DEA, against the harmful effects of BPA exposure. DEA reduced cell damage in N9 cells and improved antioxidant production in zebrafish larvae, suggesting its ability to mitigate oxidative stress and inflammation caused by BPA.

Murugan R et al (2023).
Comp Biochem Physiol C Toxicol Pharmacol.
PubMed:
37394128

Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.

New compounds with anti-inflammatory properties were found in the roots of L. These compounds showed even better effectiveness than a commonly used anti-inflammatory drug. Additionally, five of these compounds helped to enhance the effects of certain chemotherapeutic drugs against cervical cancer cells, including those resistant to paclitaxel. The combination of one particular compound and paclitaxel successfully promoted cancer cell death through a specific cellular pathway. This research could lead to new treatments for inflammatory diseases and cancer, offering hope for improved patient outcomes.

Wan Q et al (2023).
J Agric Food Chem.
PubMed:
37392181