Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice.

Cynanchum paniculatum has been traditionally utilized in East Asia as an analgesic or antiviral. Some traditional medicinal books also mention its use in treating psychotic symptoms. The study explores its potential benefits for treating schizophrenia-like symptoms in rats. The extracts showed a promising reduction in behavioral abnormalities, leading to the possibility of this plant being a useful resource in the development of antipsychotic medicines.

Bae HJ et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116627

PubMed:

37164258

Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation.

Lu CY et al (2023).

Environ Toxicol.

DOI:

10.1002/tox.23818

PubMed:

37163279

Antimicrobial, antioxidant, cytotoxicity and photocatalytic performance of Co doped ZnO nanoparticles biosynthesized using Annona Muricata leaf extract.

Vindhya PS et al (2023).

J Environ Health Sci Eng.

DOI:

10.1007/s40201-023-00851-4

PubMed:

37159742

Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension through PI3K/Akt/STAT3 pathway.

This study examines the potential of nobiletin, found in orange peel, to relieve pulmonary arterial hypertension induced by monocrotaline and investigates how it works.

Yin Q et al (2023).

J Pharm Pharmacol.

DOI:

10.1093/jpp/rgad045

PubMed:

37158759

Moringa oleifera leaf polysaccharides exert anti-lung cancer effects upon targeting TLR4 to reverse the tumor-associated macrophage phenotype and promote T-cell infiltration.

Tumor-associated macrophages (TAMs) contribute to cancer growth and metastasis. A new study shows that leaf polysaccharides can convert TAMs from immunosuppressive to antitumor, increasing T-cell infiltration and suppressing lung cancer. This highlights their potential in cancer immunotherapy.

Wang S et al (2023).

Food Funct.

DOI:

10.1039/d2fo03685a

PubMed:

37158366

Probiotic-fermented Portulaca oleracea L. alleviated DNFB-induced atopic dermatitis by inhibiting the NF-κB signaling pathway.

Zhao W et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116613

PubMed:

37156447

Evaluation of phytochemicals from Thymus serpyllum as potential drug candidates to manage oxidative stress in transition dairy cows.

Azhar J et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2023.2209190

PubMed:

37154530

Effects of Ocimum basilicum L. Extract on Hippocampal Oxidative Stress, Inflammation, and BDNF Expression in Amnesic Aged Rats.

The study investigated the effects of a plant extract (OB) on learning and memory in aged rats. Aging decreased cognitive function and increased inflammation and oxidative damage in the brain. However, OB administration for 8 weeks improved learning and memory and reduced inflammation and oxidative damage in the brain. This suggests that OB has neuroprotective effects and may be useful in treating age-related cognitive decline.

Beheshti F et al (2023).

Exp Aging Res.

DOI:

10.1080/0361073X.2023.2210240

PubMed:

37154241