Immunology Studies

Polysaccharides from sea buckthorn (Hippophae rhamnoides L.) berries ameliorates cognitive dysfunction in AD mice induced by a combination of D-gal and AlCl(3) by suppressing oxidative stress and inflammation reaction.

Hippophae rhamnoides L. has been used for centuries in traditional medicine to treat heart ailments, rheumatism, and brain disorders. Recent studies suggest that its polysaccharide (HRP) may improve cognitive impairment in mice with Alzheimer's disease, but the protective mechanism remains unclear.

Zhao H et al (2023).
J Sci Food Agric.
PubMed:
37132070

Engeletin alleviates cerebral ischemia reperfusion-induced neuroinflammation via the HMGB1/TLR4/NF-κB network.

Engeletin, derived from Smilax glabra rhizomilax, has neuroprotective effects in rats with cerebral ischemia reperfusion injury, reducing deficits, infarct size, inflammation, and apoptosis. It suppresses the HMGB1/TLR4/NF-κB inflammatory network.

Xu Y et al (2023).
J Cell Mol Med.
PubMed:
37132060

The effects of the Rheum ribes plant extract on inflammation, extracellular matrix remodeling, and obesity suggest a therapeutic potential.

Researchers investigated the Rheum ribes L. plant to understand its molecular mechanism in treating obesity and inflammation, which are linked to the rising prevalence of Type II diabetes.

Kaya H et al (2023).
Mol Biol Rep.
PubMed:
37126207

Response to Article "Evaluation of the Antioxidant and Wound Healing Properties of 80% Methanol Extract and Solvent Fractions of the Leaves of Vernonia auriculifera Hiern. (Asteraceae)" [Letter].

Intan PR, Noviantari A and Alegantina S (2023).
Clin Cosmet Investig Dermatol.
PubMed:
37123624