Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
- Ge MX et al (2023).
- Phytother Res.
- DOI:
- 10.1002/ptr.7845
- PubMed:
- 37132081
Hippophae rhamnoides L. has been used for centuries in traditional medicine to treat heart ailments, rheumatism, and brain disorders. Recent studies suggest that its polysaccharide (HRP) may improve cognitive impairment in mice with Alzheimer's disease, but the protective mechanism remains unclear.
Engeletin, derived from Smilax glabra rhizomilax, has neuroprotective effects in rats with cerebral ischemia reperfusion injury, reducing deficits, infarct size, inflammation, and apoptosis. It suppresses the HMGB1/TLR4/NF-κB inflammatory network.
Researchers investigated the Rheum ribes L. plant to understand its molecular mechanism in treating obesity and inflammation, which are linked to the rising prevalence of Type II diabetes.