Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by Piper longum extract in rats: The role of γH2AX and 8-OHdG.

A study evaluated a plant, Piper longum, for its ability to protect DNA from the harmful effects of the chemotherapy drug cyclophosphamide. The plant was tested in laboratory experiments using plasmid DNA and human blood cells. It was also tested in rats to confirm its effectiveness in preventing genomic instability, oxidative stress, and organ damage. The plant was found to protect DNA, reduce chromosome damage, prevent DNA damage, and reduce organ damage without causing toxicity. This promising finding could lead to future therapies to reduce side effects of chemotherapy.

Yadav V et al (2023).

Front Pharmacol.

DOI:

10.3389/fphar.2023.1147823

PubMed:

36969834

Efficacy and safety of TCMs with anti-inflammatory effect in patients with rheumatoid arthritis: A network meta-analysis.

This study analyzed the effectiveness and safety of Traditional Chinese Medicines (TCMs) for treating rheumatoid arthritis. TCMs have anti-inflammatory effects and are widely used in China.

Fang J et al (2023).

Front Immunol.

DOI:

10.3389/fimmu.2023.1114930

PubMed:

36969172

Mistletoe (Viscum album L.) extract attenuates ıtraconazole-ınduced acute oxidative stress and hepatocellular ınjury in rats.

Çetin ES et al (2023).

Pak J Pharm Sci.

PubMed:

36967491

Cuscuta chinensis flavonoids reducing oxidative stress of the improve sperm damage in bisphenol A exposed mice offspring.

Zhao Q et al (2023).

Ecotoxicol Environ Saf.

DOI:

10.1016/j.ecoenv.2023.114831

PubMed:

36966614

Exogenous application of carbon nanoparticles alleviates drought stress by regulating water status, chlorophyll fluorescence, osmoprotectants, and antioxidant enzyme activity in Capsicum annumn L.

Alluqmani SM and Alabdallah NM (2023).

Environ Sci Pollut Res Int.

DOI:

10.1007/s11356-023-26606-0

PubMed:

36966248

Paraquat-induced systemic inflammation and oxidative stress in rats improved by Curcuma longa ethanolic extract, curcumin and a PPAR agonist.

Ghasemi SZ et al (2023).

Toxicon.

DOI:

10.1016/j.toxicon.2023.107090

PubMed:

36965712

Development of an online UPLC-PDA-ESI-Q-TOF-MS-LOX-FLD system for rapid screening of anti-inflammatory compounds in Polygala tenuifolia Willd.

Sun M et al (2023).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2023.115353

PubMed:

36965376

Reconnoitring the antioxidant and anti-bacterial potential of different fruits after tannin acyl hydrolase mediated biotransformation.

Rippin R, Sharma AK and Beniwal V (2023).

Biotechnol Appl Biochem.

DOI:

10.1002/bab.2461

PubMed:

36965069