Brucine, a component of Strychnos nux-vomica with potential anti-tumor and anti-inflammatory effects, is limited by its toxicity, especially in the central nervous system. This study found that brucine induces death in nerve cells and astrocytes, and triggers a pathway involving PPARγ/NF-κB/caspase 3-dependent apoptosis. Brucine directly bound to caspase 3, and a caspase 3 inhibitor abolished the neurotoxicity. These findings provide insight into the toxicity mechanism of brucine and suggest a potential strategy for addressing it.
Researchers investigated the medicinal plant Del. and found eight new steroids. Through various methods, they determined the structure and activity of these compounds in reducing neuroinflammation. One compound, in particular, showed promise in reducing inflammation by blocking certain cellular pathways. This study highlights the potential therapeutic benefits of natural compounds in treating neurological disorders.