2935.
Astragalin and Isoquercitrin Isolated from Aster scaber Suppress LPS-Induced Neuroinflammatory Responses in Microglia and Mice.
Ast and Que, compounds found in chamchwi, were investigated for their anti-inflammatory effects in LPS-induced inflammation in microglial cells and the hippocampus of mice. LPS treatment increased cytotoxicity, NO production, antioxidant activity, ROS, iNOS expression, pro-inflammatory cytokines, and MAPK phosphorylation. Ast and Que reduced the production of NO, iNOS, and pro-inflammatory cytokines and inhibited MAPK kinase phosphorylation, which mediates inflammation. Ast and Que also inhibited LPS-induced ROS generation and increased radical scavenging. Overall, Ast and Que have anti-neuroinflammatory activity through down-regulation of MAPKs signaling pathways in LPS-activated microglia and the hippocampus of mice.
Kim EH et al (2022).
Foods.