Chemical Constituents of Ulmus minor subsp. minor Fruits Used in the Italian Phytoalimurgic Tradition and Their Anti-inflammatory Activity Evaluation.
- DʼAngiolo M et al (2022).
- Planta Med.
- DOI:
- 10.1055/a-1787-1342
- PubMed:
- 35240714
Geraniin, a polyphenol, was studied for its potential to protect against cerebral ischemia/reperfusion (I/R) injury. The study used both in vivo and in vitro models to evaluate the neuroprotective effect of geraniin. Geraniin showed a significant reduction in infarct volume, decreased neurological deficit scores, and reduced cell apoptosis. It also increased the activity of superoxide dismutase (SOD) and decreased the activity of lactate dehydrogenase (LDH) and malondialdehyde (MDA), suggesting its antioxidant capacity. Additionally, geraniin increased Nrf2/HO-1 protein expression in vivo and in vitro, indicating an association with the protective effect against I/R injury. Geraniin shows promise as a potential treatment for ischemic stroke.