Immunology Studies

Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them.

Anxiety disorders are prevalent and costly in the U.S. Despite available treatments, many patients experience side-effects or resistance. The COVID-19 pandemic has exacerbated the issue. Dihydromyricetin (DHM), a flavonoid found in Ampelopsis grossedentata, has been shown to have anxiolytic properties in mouse models. The authors investigated the effect of short-term social isolation on the neuroimmune system and found evidence that the GABAergic system plays a role in modulating immune response. These findings may lead to new therapies for anxiety disorders.

Al Omran AJ et al (2022).
J Neuroinflammation.
PubMed:
34983568