Immunology Studies

The Effect of Ferula communis Extract in Escherichia coli Lipopolysaccharide-Induced Neuroinflammation in Cultured Neurons and Oligodendrocytes.

Ferutinin, a compound found in the plant genus L., has properties that may benefit the treatment of neurodegenerative and demyelinating diseases. In an experimental system, human neurons and oligodendrocytes were treated with a pro-inflammatory agent and then pretreated with ferutinin. Results suggested that ferutinin may act as an antioxidant and anti-inflammatory agent. However, further studies are needed to confirm its potential use as a treatment strategy for diseases characterized by inflammation and oxidative stress.

Maiuolo J et al (2021).
Int J Mol Sci.
PubMed:
34360675

Scolymus hispanicus (Golden Thistle) Ameliorates Hepatic Steatosis and Metabolic Syndrome by Reducing Lipid Accumulation, Oxidative Stress, and Inflammation in Rats under Hyperfatty Diet.

Berdja S et al (2021).
Evid Based Complement Alternat Med.
PubMed:
34335826

Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease.

Scientists are exploring the potential of a medicinal plant extract from Centella asiatica (CA) as a solution for healthy aging. Past studies have shown that its key components exhibit anti-inflammatory, neuroprotective, and cognitive benefits, linked to the plant's antioxidant and mitoprotective properties. Mitochondrial dysfunction and oxidative stress play a significant role in aging and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Researchers believe that CA could be an effective treatment for brain aging and neurodegenerative diseases based on its antioxidative and mitoprotective effects.

Wong JH, Barron AM and Abdullah JM (2021).
Front Pharmacol.
PubMed:
34267660