Effect of Quarrying and Stone Crushing Activities on Nutritional Composition, Heavy Metals and Oxidative Stress Indices of Aspilia africana.
- Chidi Enyinnaya O et al (2020).
- Pak J Biol Sci.
- PubMed:
- 32700855
Levisticum officinale extract (LOE) has anti-inflammatory, antioxidant, and anticholinesterase activities. In a study on rats, LOE was administered at doses of 100, 200, and 400 mg kg-1 for a week and continued for 3 more weeks with lipopolysaccharide (LPS) injection to induce neuroinflammation. LOE significantly attenuated LPS-induced spatial learning and memory deficits. LPS increased the mRNA expression level of interleukin-6 in the hippocampus, accompanied by decreased brain-derived neurotrophic factor (BDNF) mRNA expression levels. LPS also increased malondialdehyde levels, reduced antioxidant enzyme activities, and impaired neurogenesis. However, pre-treatment with LOE at a dose of 100 mg kg-1 significantly reversed LPS-induced changes and improved neurogenesis. LOE's beneficial effect on learning and memory is attributed to its anti-inflammatory, antioxidant activities, and ability to increase BDNF expression and neurogenesis.