Immunology Studies

New bis-thioglycosyl-1,1'-disulfides from Nasturtium officinale R. Br. and their anti-neuroinflammatory effect.

Researchers have discovered three new bis-thioglycosides (compounds 1-3) and 13 known compounds (compounds 4-16) from the Nasturtium officinale plant family. The team used NMR techniques, HRESIMS, and a chemical method to identify the new compounds. They tested all compounds for their ability to inhibit nitric oxide levels in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells. Compound 5 demonstrated strong inhibitory effects on nitrogen production, while compounds 4 and 15 showed moderate inhibitory activity, suggesting that bis-thioglycosides could help protect the brain and reduce inflammation.

Lee TH et al (2019).
Bioorg Chem.
PubMed:
30776680