Nitric oxide inhibitory limonoids as potential anti-neuroinflammatory agents from Swietenia mahagoni.

Researchers have isolated seven limonoids from Swietenia mahagoni which have potential use as anti-neuroinflammatory agents in treating Alzheimer's disease. Three of the compounds were previously known and four were newly discovered. All of the compounds showed anti-neuroinflammatory activity by inhibiting nitric oxide release in cells. One compound in particular, coded as Compound 5, showed the highest inhibition of nitric oxide release. The researchers investigated the possible mechanism of the compounds and found they interact with the inducible nitric oxide synthase protein. These findings suggest that Swietenia mahagoni may contain useful compounds for treating neuroinflammation in Alzheimer's disease.

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