Obesity Studies

Uncovering the anti-obesity constituents in Ginkgo biloba extract and deciphering their synergistic effects.

Ginkgo biloba extract (GBE50) contains bioflavonoids and several flavonoids that inhibit human pancreatic lipase (hPL), potentially enhancing its anti-obesity effects.

Zhang M et al (2023).
Fitoterapia.
PubMed:
37683877

Obesity theranostics using nanoemulsions of probiotics and local herbs.

Researchers formulated nanoemulsions of probiotics and local herbs to assess their therapeutic potential in obese rats. The combination significantly improved body weight, liver and kidney function, and histology. Probiotics and local herbs may be a complementary option for obesity treatment.

Alam S et al (2023).
Saudi J Biol Sci.
PubMed:
37680978

Compound chenpi tea consumption reduces obesity-related metabolic disorders by modulating gut microbiota and serum metabolites in mice.

Scientists studied the anti-obesity effect of chenpi tea, made from citri reticulatae pericarpium, Ganoderma lucidum, and pu-erh tea, in mice on a high-fat diet. They used RNA sequencing and metabolomic analysis to identify potential mechanisms.

Wang J et al (2024).
J Sci Food Agric.
PubMed:
37638783

Hibiscus sabdariffa Linn. Extract Increases the mRNA Expression of the Arcuate Nucleus Leptin Receptor and is Predicted in silico as an Anti-obesity Agent.

Leptin helps regulate body weight by increasing energy expenditure. It also promotes browning of fat cells. However, in obese individuals, the receptors for leptin and a key protein are decreased.

Kartinah NT et al (2023).
Curr Comput Aided Drug Des.
PubMed:
37608673

Ophiopogonin D ameliorates non‑alcoholic fatty liver disease in high‑fat diet‑induced obese mice by improving lipid metabolism, oxidative stress and inflammatory response.

This study examined the effects of Ophiopogonin D (OP-D) on non-alcoholic fatty liver disease (NAFLD) in mice. OP-D was found to improve NAFLD by regulating lipid metabolism, antioxidant, and anti-inflammatory responses. OP-D also reduced lipogenesis and inflammation, potentially through the NF-κB signaling pathway.

Huang X et al (2023).
Exp Ther Med.
PubMed:
37602303

Oxymatrine relieves high-fructose/fat-induced obesity via reprogramming the activity of lipid metabolism-related enhancer.

Researchers studied the effects of a high-fructose and high-fat diet on obesity and fatty liver disease. Their findings can help develop new treatments for these common metabolic disorders.

Ren L et al (2023).
Front Endocrinol (Lausanne).
PubMed:
37600712

Salvia Officinalis Improves Glucose Uptake and Suppresses Ectopic Lipid Deposition in Obese Rats with Metabolic Syndrome.

Researchers studied the effects of Salvia officinalis (SAGE) on obesity and type 2 diabetes. SAGE showed potential as an anti-diabetic and anti-obesity agent in rats.

ALsherif DA et al (2023).
Curr Pharm Biotechnol.
PubMed:
37581324

Supplementation with spinach-derived thylakoid augments the benefits of high intensity training on adipokines, insulin resistance and lipid profiles in males with obesity.

This study examined the impact of intense functional training combined with spinach supplement on certain hormones and insulin resistance in obese males.

Saeidi A et al (2023).
Front Endocrinol (Lausanne).
PubMed:
37576981