Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1.
- Lee HS et al (2019).
- Nutrients.
- DOI:
- 10.3390/nu11102475
- PubMed:
- 31618980
The study assessed the potential of an ethyl acetate fraction from var. (EFAD) on metabolic syndrome induced by a high-fat diet (HFD). Results showed that EFAD reduces lipid accumulation, improves insulin resistance, and has ameliorating effects on obesity-induced cognitive disorder, oxidative stress, and mitochondrial dysfunction. In tests, EFAD significantly suppressed the increase of body weight and improved glucose tolerance in obese mice. The study confirmed that EFAD positively impacts the peripheral-IR and CNS-IR, which are factors in neurodegeneration such as Alzheimer's disease. The results suggest EFAD may be used for the prevention of neurodegeneration by improving metabolic syndrome caused by HFD.
This study investigated the effectiveness and safety of a particular extract from V. arctostaphylos berries in treating hypertension in overweight/obese patients.