Pain Studies

Phyto-pharmacological and computational profiling of Bombax ceiba Linn. Leaves revealed pharmacological properties against oxidation, hyperglycemia, pain, and diarrhea.

Study isolated compounds from plant leaves, showing potential for antioxidant, analgesic, hypoglycemic, and anti-diarrheal properties. Further research needed for exact mechanisms, but promising for potential medicinal use.

Taher MA et al (2024).
Heliyon.
PubMed:
39170236

Toxic and signaling effects of the anaesthetic lidocaine on rice cultured cells.

Study shows lidocaine affects rice cells similarly to mammals, inducing programmed cell death and disrupting electrical signals. Important for understanding anesthesia mechanisms across species.

Sylvain Bonfanti L et al (2024).
Plant Signal Behav.
PubMed:
39116108

Analgesic Effect of SKI306X on Chronic Postischemic Pain and Spinal Nerve Ligation-Induced Neuropathic Pain in Mice.

"SKI306X, made from three oriental herbs, reduces neuropathic pain in mice with chronic postischemic pain and spinal nerve ligation. It shows dose-dependent antiallodynic effects by decreasing GFAP levels."

Quan J et al (2024).
Biomedicines.
PubMed:
39061952

Inula helenium extract and lidocaine-loaded electrospun wound dressings for managing skin wounds pain and their healing: An in vitro and in vivo study.

Scientists developed nanofiber dressings loaded with extract and lidocaine to promote wound healing and reduce pain. In vitro and rat model studies showed slow drug release, antioxidant, anti-inflammatory effects, reduced bacterial infiltration, and significant wound closure. These dressings also decreased pain sensitivity and inflammation in animals.

Wang H et al (2024).
J Biomater Appl.
PubMed:
39042854

ZY5301 Tablet vs Placebo for Treatment of Chronic Pelvic Pain After Pelvic Inflammatory Disease: A Phase 2 Randomized Clinical Trial.

ZY5301 tablets from Ajuga decumbens are being tested for treating chronic pelvic pain caused by pelvic inflammatory disease. Important potential treatment for a major issue with no established cure.

Teng X et al (2024).
JAMA Netw Open.
PubMed:
39042407

Molecular mechanisms of Schisandra chinensis in treating depression-neuropathic pain comorbidity by network pharmacology and molecular docking analysis.

Study identified bioactive components in Schisandra chinensis for treating neuropathic pain/depressive disorder comorbidity. Components regulate pathways involving TNF, VEGF, and GH, providing insights into molecular mechanisms for potential novel therapies.

Mokhtari T and El-Meghawry El-Kenawy A (2024).
Neuroscience.
PubMed:
39032805

Efficacy of aromatherapy with Lavandula angustifolia oil on postoperative pain after cardiac surgery: A randomized clinical trial.

Aromatherapy with Lavandula angustifolia essential oil reduced postoperative pain in cardiac surgery patients. Promising for non-pharmacological pain management post-surgery.

Silva LCMA et al (2024).
Explore (NY).
PubMed:
39032323
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