Pain Studies

In vivo and in silico elucidation of possible potential and mechanisms involved in the analgesic action of ethanolic extract of Lavandula Stoechas.

Researchers studied Lavandula stoechas flower extract for potential pain relief effects and pathways involved. Essential for understanding plant-based analgesics for future medical applications.

Nazir MM et al (2024).
J Pharm Pharmacol.
PubMed:
38984979

Efficacy of soothing cream gel in the range of motion and chronic pain at the shoulder and elbow: protocol of a double-blinded, randomised, placebo-controlled trial.

SCG cream gel may improve range of motion and chronic pain in shoulder and elbow, reducing the need for traditional treatments with undesirable side effects. Consider using SCG as an alternative therapy for upper limb problems.

Lo CW et al (2024).
BMJ Open.
PubMed:
38969378

Chemical compounds, anti-tumor and anti-neuropathic pain effect of hemp essential oil in vivo.

Study extracted and analyzed hemp essential oil (HEO) components, showing potential anti-tumor and anti-neuropathic pain effects. HEO reduced inflammatory cytokines and inhibited tumor growth in mice models, suggesting potential in cancer treatment and medicinal development of hemp.

Xu Y et al (2024).
Fitoterapia.
PubMed:
38914272

In vivo analgesic, anti-inflammatory, sedative, muscle relaxant activities, and docking studies of 3',4',7,8-tetrahydroxy-3-methoxyflavone isolated from Pistacia chinensis.

Isolated a compound from medicinal plant; studied its therapeutic effects. Potential new natural remedy worth exploring further in lab research.

Rauf A et al (2024).
Drug Target Insights.
PubMed:
38903608

Evaluation of anti-nociceptive and anti-inflammatory activities of solvent fraction of the roots of Echinops kebericho Mesfin (Asteraceae) in mice model.

Scientists studied the pain-relieving and anti-inflammatory effects of a plant's root extract in animals. This research could lead to new treatments for pain and swelling.

Tadesse TY et al (2024).
J Complement Integr Med.
PubMed:
38887090

Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice.

Arecoline from Areca nut may alleviate pain, anxiety, and depression through muscarinic receptors in the anterior cingulate cortex. Potential future treatment for chronic pain and related disorders.

Chen QY et al (2024).
Mol Brain.
PubMed:
38886822

Formulation of Phytosomes Containing Rubia cordifolia Extract for Neuropathic Pain: In Vitro and In Vivo Evaluation.

Researchers developed a phytosome delivery system for a plant extract with strong antioxidant properties. Formulation improved bioavailability of key compound, leading to increased neuroprotective effects and pain relief potential in nerve damage. Encapsulation may enhance treatment for neuropathic pain.

Kumar N et al (2024).
ACS Omega.
PubMed:
38882167

Select Minor Cannabinoids from Cannabis sativa are Cannabimimetic and Antinociceptive in a Mouse Model of Chronic Neuropathic Pain.

Researchers tested 5 minor cannabinoids in mice for pain relief and cannabimimetic behaviors. Findings show potential differences between compounds and sexes, warranting further investigation into therapeutic benefits of minor cannabinoids. Significant for understanding effects of lesser-studied compounds in marijuana.

Schwarz AM et al (2024).
J Pharmacol Exp Ther.
PubMed:
38834356
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