Pain Studies

Behavioral and electrophysiological study in Colossoma macropomum treated with different concentrations of Nepeta cataria oil in an immersion bath revealed a therapeutic window for anesthesia.

Essential oils from Nepeta Cataria induce anesthesia in fish. Concentrations of 125-150µL-1 safe for short-term use, with reversible effects on posture reflex. Electrocardiographic changes observed at higher concentrations.

Dos Santos MF et al (2024).
Fish Physiol Biochem.
PubMed:
38801500

The Analgesic Potential of Litsea Species: A Systematic Review.

Studies found that species from the genus have analgesic properties, with 9 species showing potential for pain relief through various mechanisms. These plants could be developed as alternatives to prescription drugs for pain management.

Goh MPY et al (2024).
Molecules.
PubMed:
38731572

Fabrication of Multifunctional Nanocomposite Fiber Extracted from Sambucus nigra: Anti-nociceptive, Anti-inflammatory, Self-Cleaning, and UV Blocking.

Chemical compounds from Sambucus nigra were used to create nanofabric doping/undoping nano-zinc oxide particles with anti-nociceptive and anti-inflammatory effects. Improved self-cleaning and UV-blocking properties were also observed.

Davodiroknabadi A et al (2024).
Appl Biochem Biotechnol.
PubMed:
38683452

A novel isoquinoline alkaloid HJ-69 isolated from Zanthoxylum bungeanum attenuates inflammatory pain by inhibiting voltage-gated sodium and potassium channels.

Scientists studied isoquinoline alkaloids in Z. bungeanum for potential medicinal benefits. This plant has traditional use for arthritis and toothache in Asia. Research may lead to new treatments.

Wang L et al (2024).
J Ethnopharmacol.
PubMed:
38677570

Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury.

Researchers explored the analgesic properties of Ligustilide from Angelica sinensis and Ligusticum chuanxiong. Understanding TRP channels' involvement in pain relief could lead to improved treatments for dysmenorrhea, migraines, and arthritis.

Zhang K et al (2024).
J Ethnopharmacol.
PubMed:
38641072

Anti-Inflammatory, Analgesic, Functional Improvement, and Chondroprotective Effects of Erigeron breviscapus (Vant.) Hand.-Mazz. Extract in Osteoarthritis: An In Vivo and In Vitro Study.

East Asian herbal medicine EB shows potential as a treatment for osteoarthritis by reducing inflammation and pain, and inhibiting cartilage destruction. Further research is needed to confirm its efficacy.

Jo HG et al (2024).
Nutrients.
PubMed:
38613068

Phytochemical, Pharmacological, and Molecular Docking Study of Dry Extracts of Matricaria discoidea DC. with Analgesic and Soporific Activities.

Researchers developed novel processing methods to obtain essential oil and extracts from Pineapple weed, known for anti-inflammatory properties. In vivo studies demonstrated analgesic and soporific effects, with potential for COX inhibition and NMDA receptor antagonism.

Sepp J et al (2024).
Biomolecules.
PubMed:
38540779

Plant-Produced Therapeutic Crizanlizumab Monoclonal Antibody Binds P-Selectin to Alleviate Vaso-occlusive Pain Crises in Sickle Cell Disease.

Scientists cloned and expressed anti-P-selectin antibody genes in tobacco plants, successfully producing biofunctional therapeutic monoclonal antibody Crimab for Sickle Cell Disease treatment. This method can offer a cost-effective and scalable production alternative for essential treatments.

Yang T et al (2024).
Mol Biotechnol.
PubMed:
38491245