Pain Studies

8-shogaol derived from dietary ginger alleviated acute and inflammatory pain by targeting TRPV1.

TL;DR: 8-Shogaol (8S) in ginger reduces inflammatory pain and morphine tolerance by activating TRPV1 channels. Potential new drug for pain relief.

ImmunologyPain Zingiber officinale
Cheng XL et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155500
PubMed:
38484627

The Incidence of Postoperative Complications Following Lumbar and Bone Marrow Punctures in Pediatric Anesthesia: Insights From APRICOT.

Researchers investigated complications during bone marrow aspirations and lumbar punctures in children with cancer. Understanding risks can improve safety and decision-making in pediatric oncology procedures.

NeurosciencePain Prunus armeniacaPrunus armeniaca 
Dagher K et al (2024).
J Pediatr Hematol Oncol.
DOI:
10.1097/MPH.0000000000002849
PubMed:
38447107

Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels.

Scientists studied Schisandra chinensis for its analgesic properties. The extract showed analgesic activity but the active component and mechanisms are unknown. Important for potential pain management discoveries.

Pain Schisandra chinensis
Zhao M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117996
PubMed:
38431110

Baccharis dracunculifolia DC Consumption Improves Nociceptive and Depressive-like Behavior in Rats with Experimental Osteoarthritis.

DC extract from Brazilian plant reversed chronic pain and emotional impairments in osteoarthritic rats. Contains anti-inflammatory compounds, potential for nutraceuticals and functional foods.

NeurosciencePain Baccharis dracunculifolia
Laranjeira IM et al (2024).
Foods.
DOI:
10.3390/foods13040535
PubMed:
38397516

Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights.

Researchers reviewed studies on nutraceuticals for infants and children with abdominal pain and gut-brain disorders. They found that fennel, herbal extracts, DSM 17938, BB-12, peppermint oil, psyllium fibers, corn fiber cookies, guar gum, and vitamin D showed potential in reducing pain. However, more research is needed to confirm their efficacy and safety.

GastroenterologyNeurosciencePain Mentha piperita
Salvatore S et al (2024).
Nutrients.
DOI:
10.3390/nu16030349
PubMed:
38337634

Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain.

Study evaluated the efficacy of L. [Piperaceae] in inhibiting pain and joint destruction in osteoarthritis (OA). Network analysis and molecular docking predicted potential targets and pathways. Results showed that L. [Piperaceae] may be a disease-modifying OA drug candidate.

ArthritisImmunologyPain Piper longum
Jo HG et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1282943
PubMed:
38328576

Exploration of the anti-inflammatory, analgesic, and wound healing activities of Bletilla Striata polysaccharide.

BSP, a component of Bletilla Striata plant, was tested in mice for its effects on inflammation, antioxidant levels, pain relief, and wound healing. Results showed BSP reduced inflammation, improved antioxidant levels, relieved pain, and promoted wound healing by inhibiting inflammatory cytokines.

ImmunologyPain Bletilla striata
He X et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129874
PubMed:
38307430

Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives.

Researchers found that traditional Chinese medicine (TCM) can effectively manage cancer pain by tonifying, clearing, and activating channels and meridians. This approach may offer a new strategy for alleviating pain without the adverse effects of conventional medications.

CancerPain Cynanchum otophyllum
Ji J et al (2024).
Am J Chin Med.
DOI:
10.1142/S0192415X24500058
PubMed:
38281918
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