Pain Studies

Euphorbia tirucalli latex loaded polymer nanoparticles: Synthesis, characterization, in vitro release and in vivo antinociceptive action.

Researchers encapsulated the active substance-containing latex from Euphorbia tirucalli in poly(D,L-lactide-co-glycolide) nanoparticles. These nanoparticles showed good drug encapsulation and release profiles, making them a promising drug delivery device with potential pain-relieving effects.

Pain Euphorbia tirucalli
Rodrigues ML et al (2022).
PLoS One.
DOI:
10.1371/journal.pone.0274432
PubMed:
36445864

Anti-Inflammatory and Analgesic Activity of Methanolic Root Extract of Verbascum sinaiticum Benth.

This study explored the pain-relieving and anti-inflammatory effects of a plant extract called Benth (VS) to potentially find a safer alternative to NSAIDs and opioids.

ImmunologyPain Verbascum sinaiticum
Asefa M, Teshome N and Degu A (2022).
J Inflamm Res.
DOI:
10.2147/JIR.S389430
PubMed:
36444312

Isolation and characterization of carpaine and dihydroxy derivative of carpaine from leaves of Carica papaya: Development of fast HPLC method and standardization of formulations.

This study isolated and identified carpaine, a major alkaloid, from dried Carica papaya leaves. A fast HPLC method was developed to quantify carpaine in leaf extract and marketed formulations.

Pain Carica papaya
Jadhav K et al (2022).
J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:
10.1016/j.jchromb.2022.123533
PubMed:
36442395

The Effect of Malva Sylvestris Cream on Episiotomy Pain and Healing: A Randomized Controlled Clinical Trial.

Study in Iran examined the impact of Malva Sylvestris cream on pain and healing for women undergoing episiotomy during childbirth. Results could improve postpartum care.

Pain Malva sylvestris
Mohaghegh Z et al (2022).
Int J Community Based Nurs Midwifery.
DOI:
10.30476/IJCBNM.2022.95772.2082
PubMed:
36274662

The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.

Researchers screened natural products to find small molecules that target voltage-gated sodium and calcium channels involved in pain processing. These findings are important as they could lead to alternative therapies for chronic pain, reducing dependence on opioids.

NeurosciencePain Parthenium incanum
Duran P et al (2022).
Br J Pharmacol.
DOI:
10.1111/bph.15974
PubMed:
36245395

The Structural, Biological, and In-Silico Profiling of Novel Capryloyl Tetra-Glucoside and Aliphatic Ester Constituents from the Abutilon indicum Offers New Perspectives on the Treatment of Pain and Inflammation.

Peeli booti plant from India was studied to identify and evaluate its ability as an anti-inflammatory and analgesic. Two novel compounds were found with potential therapeutic targets for development of such drugs.

ImmunologyPain Abutilon indicum
Wahab S et al (2022).
Plants (Basel).
DOI:
10.3390/plants11192583
PubMed:
36235451

Effects of Capparis Spinosa extract on the neuropathic pain induced by chronic constriction injury in rats.

The study investigated the effects of Capparis Spinosa extract on neuropathic pain in rats. Results showed that the extract reduced pain by exhibiting antioxidative and anti-inflammatory effects, possibly due to its flavonoid compounds. This could have implications for the development of new treatments for neuropathic pain.

Pain Capparis spinosa
Rakhshandeh H et al (2022).
Metab Brain Dis.
DOI:
10.1007/s11011-022-01094-2
PubMed:
36222985

The effect of Dioscorea esculenta powder on prostaglandin E(2) and cytochrome c oxidase subunit 2 levels, menstrual pain, and premenstrual syndrome in young women: A randomized double-blind controlled trial.

Diosgenin intake (300 mg/day) for 4 weeks decreased PGE and COX-2 levels, improving PMS symptoms and menstrual pain in young women.

Pain Dioscorea esculenta
Sato K and Seto K (2022).
Nutr Health.
DOI:
10.1177/02601060221130889
PubMed:
36217795
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