Pain Studies

Kratom Alkaloids, Cannabinoids, and Chronic Pain: Basis of Potential Utility and Role in Therapy.

This review discusses the potential therapeutic benefits of using kratom and cannabis compounds together for chronic pain. More research is needed to understand their effectiveness.

Farkas DJ et al (2023).
Cannabis Cannabinoid Res.
PubMed:
37466474

Papaver rhoeas L. stem and flower extracts: Anti-struvite, anti-inflammatory, analgesic, and antidepressant activities.

L. () plant extracts have anti-struvite, anti-inflammatory, analgesic, and antidepressant effects, containing secondary metabolites that inhibit struvite crystal formation. Promising for pharmaceutical use due to bioactive properties.

Hmamou A et al (2023).
Saudi Pharm J.
PubMed:
37448842

Solasodine Containing Solanum torvum L. Fruit Extract Prevents Chronic Constriction Injury-Induced Neuropathic Pain in Rats: In Silico and In Vivo Evidence of TRPV1 Receptor and Cytokine Inhibition.

In this study, researchers investigated the efficacy of an extract from Solanum torvum L. fruit in treating neuropathic pain in rats. They found that the extract significantly reduced pain and biochemical changes associated with the condition. Their findings suggest that this extract may have potential as a treatment for neuropathic pain.

Jain V et al (2023).
Mol Neurobiol.
PubMed:
37314657

Parthenolide as a potential analgesic in the treatment of paclitaxel-induced neuropathic pain: the rat modeling.

Parthenolide, found in Tanacetum parthenium, was tested on rats with neuropathic pain caused by paclitaxel. PTL treatment at 4 mg/kg effectively reduced pain, regulated gene and protein expression, and improved tissue damage.

Toraman E et al (2023).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
37306715

The ethanol extract of Scutellaria baicalensis Georgi attenuates complete Freund's adjuvant (CFA)-induced inflammatory pain by suppression of P2X3 receptor.

Researchers investigated the effects of Scutellaria baicalensis Georgi (SGE) on inflammatory pain. SGE extracted from the herb showed anti-inflammatory and analgesic properties, potentially making it useful for treating inflammation-related diseases. However, more research is needed to fully understand its mechanisms.

Gao L et al (2023).
J Ethnopharmacol.
PubMed:
37301308

A Blend of Tamarindus Indica and Curcuma Longa Extracts Alleviates Monosodium Iodoacetate (MIA)-Induced Osteoarthritic Pain and Joint Inflammation in Rats.

TamaFlex, a herbal supplement, reduces knee joint pain and improves musculoskeletal functions in healthy and osteoarthritis subjects. This study investigates its molecular basis in rat models with induced OA.

Kwon SB et al (2023).
J Am Nutr Assoc.
PubMed:
37224433

Nanoencapsulation and characterisation of Hypericum perforatum for the treatment of neuropathic pain.

Researchers encapsulated an extract into nanophytosomes and tested its effectiveness in treating neuropathic pain caused by nerve damage.

Goel R et al (2023).
J Microencapsul.
PubMed:
37191895

Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport.

This study explores the harmful effects of opioids, their impact on addiction and overdose, and the involvement of the mesocorticolimbic dopaminergic circuitry. It also addresses the use of synthetic opioids in athletes and the potential for doping.

Mazzeo F, Meccariello R and Guatteo E (2023).
Int J Mol Sci.
PubMed:
37175536