Cannabis constituents for chronic neuropathic pain; reconciling the clinical and animal evidence.

Recent preclinical studies suggest that THC-containing cannabis extracts have limited effectiveness and are associated with side effects. Therefore, it is important to focus on targeting channels and receptors other than cannabinoid CB1 receptors to improve the treatment of chronic neuropathic pain.

Sokolaj E et al (2023).

J Neurochem.

DOI:

10.1111/jnc.15964

PubMed:

37747128

Chemical characterization, anti-struvite crystal, anti-inflammatory, analgesic, and antidepressant activities of Papaver rhoeas L. root and leaf extracts.

Scientists investigated the effects of root and leaf extracts from Papaver rhoeas on struvite crystals, inflammation, pain, and depression. No previous data available. Useful for potential treatment applications.

Hmamou A et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117208

PubMed:

37739099

The oral administration of Lotus corniculatus L. attenuates acute and chronic pain models in male rats.

Researchers investigated the anti-inflammatory and analgesic effects of Lotus corniculatus L. extract. It may have potential as a natural remedy for peritoneal inflammation and back pain.

Jabbari S et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117181

PubMed:

37734474

Cold pressed Pinus halepensis Mill. seed oil for potential health applications: Analgesic, anti-inflammatory effects, and assessment of inflammatory mediators by RT-qPCR in skin wound healing.

The researchers investigated the medicinal properties of Pinus halepensis seed, which is commonly consumed in the Mediterranean region. It has been traditionally used to treat various diseases.

Ait Atmane S et al (2024).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117157

PubMed:

37696441

Anti-urolithiatic, antibacterial, anti-inflammatory and analgesic effects of Erica arborea flowers and leaves hydromethanolic extracts: An ethnopharmacological study.

The study investigates the medicinal use of L. plant in Algeria, specifically its anti-urolithiatic, antibacterial, anti-inflammatory, and analgesic effects. Results show significant activity in all tested areas, making it a potential natural source for drugs with these effects.

Amari S et al (2023).

Saudi J Biol Sci.

DOI:

10.1016/j.sjbs.2023.103785

PubMed:

37680977

Synergistic effects of Boswellia serrata and Acmella oleracea extract combination for treating neuropathic pain in a preclinical model of spared nerve injury.

Boccella S et al (2023).

Phytother Res.

DOI:

10.1002/ptr.8001

PubMed:

37661796

A chromosome-level genome assembly of anesthetic drug-producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids.

Researchers studied Tropane alkaloids in Anisodus acutangulus to understand its genome and biosynthesis pathways. This can lead to better manipulation of plants for anesthetic, analgesic, and spasmolytic effects.

Zhou W et al (2024).

Plant Commun.

DOI:

10.1016/j.xplc.2023.100680

PubMed:

37660252

Sida cordifolia L. attenuates behavioral hypersensitivity by interfering with KIF17-NR2B signaling in rat model of neuropathic pain.

Study investigated the effectiveness of Sida cordifolia L. roots in relieving neuropathic pain. Despite its traditional use, there is a lack of scientific evidence supporting this claim.

Tiwari V and Hemalatha S (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.117085

PubMed:

37640257