Phytochemistry Studies

Gastroprotective activity and physicochemical analysis of carboxymethylated gum from Anadenanthera colubrina.

Researchers modified red angico gum to create a compound with better properties for treating gastric ulcers and reduced damage from alcohol exposure.

Chaves LS et al (2024).
Int J Biol Macromol.
PubMed:
38219933

Network pharmacology and experimental validation of effects of total saponins extracted from Abrus cantoniensis Hance on acetaminophen-induced liver injury.

Abrus cantoniensis herb (ACS) is a Chinese medicine used for hepatitis treatment. It has protective effects on liver injuries, but its influence on drug-induced liver injury (DILI) remains unproven.

He J et al (2024).
J Ethnopharmacol.
PubMed:
38219885

Flavonoid extracts of Citrus aurantium L. var. amara Engl. Promote browning of white adipose tissue in high-fat diet-induced mice.

Researchers investigated the potential of Citrus aurantium L. var. amara Engl. (CAVA) blossom in combating obesity by enhancing the browning of white adipose tissue (WAT). The study builds on previous findings indicating CAVA's anti-obesity potential.

Lin SX et al (2024).
J Ethnopharmacol.
PubMed:
38219880

Brunonianines A-C, C(20)-diterpenoid alkaloids with cyano group from Delphinium brunonianum Royle.

Researchers isolated three rare C-diterpenoid alkaloids with a cyano functional group from a plant. One compound showed better inhibitory activity against cancer cells than a current drug. It also arrested cells in the G2/M phase and induced apoptosis by activating a specific signaling pathway.

Li Q et al (2024).
Phytochemistry.
PubMed:
38218306

Transcriptome analysis reveals cadmium exposure enhanced the isoquinoline alkaloid biosynthesis and disease resistance in Coptis chinensis.

Study identifies molecular mechanisms behind cadmium accumulation in medicinal herb Coptis chinensis, offers strategies to control and mitigate accumulation, enhance resistance, and promote synthesis of secondary metabolites.

Li X et al (2024).
Ecotoxicol Environ Saf.
PubMed:
38218103

A strategy of accuracy quantification by extending the concentration monitoring coverage based on online double collision energy of ultra-high performance liquid chromatography tandem mass spectrometry: The pharmacokinetics of Toddalia asiatica as a case study.

Scientists developed a method called ODCE with UHPLC-MS/MS to measure compounds in traditional Chinese medicines. This strategy allows for wider range quantification and is useful for monitoring the effectiveness and safety of TCMs.

Wang R et al (2024).
J Chromatogr A.
PubMed:
38217962

Two novel alkaloids from Portulaca oleracea L. and their anti-inflammatory bioactivities.

Two new alkaloids, Oleracrylimide D and Oleracrylimide E, were discovered in L. Their structures were identified using spectroscopic methods, and their anti-inflammatory properties were investigated using ELISA.

Wang C et al (2024).
Nat Prod Res.
PubMed:
38217487

Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials.

PNS from Panax notoginseng can treat COPD with HCS by reducing blood clotting. Important for managing risk factors in COPD patients.

Zhou R et al (2024).
Phytomedicine.
PubMed:
38216446